{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:01:17Z","timestamp":1792033277806,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The rabies virus causes a fatal encephalitis and can be transmitted through organ transplantation. In 2013, a man developed rabies 18\u00a0months after receiving a kidney from a donor with rabies, who was not known to have been infected when the organs were procured. Three additional persons who received organs from the same donor (liver, kidney, heart), all of whom were not vaccinated for rabies before transplantation, received rabies post\u2010exposure prophylaxis (<jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>) with rabies immune globulin and 5 doses of rabies vaccine as soon as the diagnosis of rabies was made in the donor (18\u00a0months after their transplant surgeries). We describe their clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As the 3 recipients were all on immunosuppressive medications, post\u2010vaccination serologic testing was performed using the rapid fluorescent focus inhibition test to measure rabies virus neutralizing antibodies (<jats:styled-content style=\"fixed-case\">RVNA<\/jats:styled-content>s). An acceptable antibody response to administration of rabies vaccine was defined as detection of <jats:styled-content style=\"fixed-case\">RVNA<\/jats:styled-content>s at a concentration \u22650.1\u00a0IU\/mL from a serum specimen collected \u22657\u00a0days after the fifth vaccine dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 3 recipients demonstrated an acceptable antibody response despite their immunosuppressed states. More than 36\u00a0months have passed since their transplant surgeries, and all 3 recipients have no evidence of rabies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The survival of 3 previously unvaccinated recipients of solid organs from a donor with rabies is unexpected. Although the precise factors that led to their survival remain unclear, our data suggest that <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> can possibly enhance transplant safety in settings in which donors are retrospectively diagnosed with rabies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12393","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T15:03:49Z","timestamp":1428419029000},"page":"389-395","source":"Crossref","is-referenced-by-count":24,"title":["Clinical management and humoral immune responses to rabies post\u2010exposure prophylaxis among three patients who received solid organs from a donor with rabies"],"prefix":"10.1111","volume":"17","author":[{"given":"N.M.","family":"Vora","sequence":"first","affiliation":[{"name":"Epidemic Intelligence Service Centers for Disease Control and Prevention (CDC) Atlanta Georgia USA"},{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Orciari","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Niezgoda","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Selvaggi","sequence":"additional","affiliation":[{"name":"Miami Transplant Institute University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Stosor","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"G.M.","family":"Lyon","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Epidemic Intelligence Service Centers for Disease Control and Prevention (CDC) Atlanta Georgia USA"},{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gabel","sequence":"additional","affiliation":[{"name":"Georgia Department of Public Health Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Stanek","sequence":"additional","affiliation":[{"name":"Florida Department of Health Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Florida Department of Health Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shiferaw","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Yager","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Hanlon","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Damon","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Blanton","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Recuenco","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Franka","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"issue":"5","key":"e_1_2_6_2_1","first-page":"360","article-title":"Re\u2010evaluating the burden of rabies in Africa and Asia","volume":"83","author":"Knobel DL","year":"2005","journal-title":"Bull World Health Organ"},{"issue":"3","key":"e_1_2_6_3_1","first-page":"1","article-title":"Human rabies 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