{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:41:11Z","timestamp":1761489671228},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toxoplasmic encephalitis represents a rare, but often fatal infection after allogeneic hematopoietic stem cell transplantation. Polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>)\u2010based preemptive therapy is considered promising for this disease, but is not routinely applied, especially in low seroprevalence countries including Japan. We encountered 2 cases of toxoplasmic encephalitis after transplantation that were successfully treated. The diagnosis of toxoplasmic encephalitis in these cases was confirmed by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> testing when neurological symptoms were observed. Both patients received pyrimethamine and sulfadiazine treatments within 2\u00a0weeks of the development of neurological symptoms, and remained free of recurrence for 32 and 12\u00a0months. These results emphasized the importance of the <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> test and immediate treatment after diagnosis for the management of toxoplasmic encephalitis.<\/jats:p>","DOI":"10.1111\/tid.12401","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T11:49:19Z","timestamp":1431517759000},"page":"593-598","source":"Crossref","is-referenced-by-count":8,"title":["Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two case reports and review of the literature"],"prefix":"10.1111","volume":"17","author":[{"given":"T.","family":"Miyagi","sequence":"first","affiliation":[{"name":"Department of Hematology Heartlife Hospital Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Itonaga","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital Sasebo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Aosai","sequence":"additional","affiliation":[{"name":"Department of Infection and Host Defense Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Infection and Host Defense Graduate School of Medicine Shinshu University Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit Atomic Bomb Disease Institute Nagasaki University Nagasaki City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Norose","sequence":"additional","affiliation":[{"name":"Department of Infection and Host Defense Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nagasaki University Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nagasaki University Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Furumoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nagasaki University Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ohama","sequence":"additional","affiliation":[{"name":"Department of Hematology Heartlife Hospital Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Karimata","sequence":"additional","affiliation":[{"name":"Department of Hematology Heartlife Hospital Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yamanoha","sequence":"additional","affiliation":[{"name":"Department of Hematology Heartlife Hospital Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital Sasebo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital Sasebo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Hematology Heartlife Hospital Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital Sasebo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Laboratory of Hematoimmunology Department of Clinical Laboratory Sciences School of Health Sciences Faculty of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Masuzaki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Hematology, Rheumatology (Second Department of Medicine) Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit Atomic Bomb Disease Institute Nagasaki University Nagasaki City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20537"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02091.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.102"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702370"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.102"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/426447"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/651266"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00919.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.494260"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7837"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/595709"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.04.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/317471"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703425"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1406-5"},{"issue":"1","key":"e_1_2_5_17_1","first-page":"211","article-title":"Pulmonary toxoplasmosis after allogeneic bone marrow transplantation: case report and review","volume":"18","author":"Saad R","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.167"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700736"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.003001024.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.646-648.2006"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702396"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-0018-3"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1379-8"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.5313-5316.2003"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.06.019"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.8.1787-1792.1989"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.2.324"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0962-9"},{"issue":"5","key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1542\/peds.67.5.653","article-title":"Toxoplasmosis a treatable neurologic disease in the immunologically compromised patient","volume":"67","author":"Emerson RG","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/317548"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00735.x"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12401","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:01:44Z","timestamp":1695542504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/tid.12401"],"URL":"https:\/\/doi.org\/10.1111\/tid.12401","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}