{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:39:40Z","timestamp":1789011580146,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) reactivation following hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) is common. To help reduce its incidence and to identify predictive factors for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation after autologous <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> (auto\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>), we conducted a retrospective analysis in patients with hematologic malignancy at our hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010hospital observational trial with a retrospective case\u2010control analysis of post\u2010auto\u2010<jats:styled-content style=\"fixed-case\">SCT VZV<\/jats:styled-content> reactivation in patients with malignant lymphoma (<jats:styled-content style=\"fixed-case\">ML<\/jats:styled-content>) and multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) between January 2001 and December 2010, in the Department of Hematology at our hospital. First, we analyzed the cumulative incidence of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation during the post\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> period. Second, we conducted a case\u2010control analysis to identify the risk factors for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation within 1\u00a0year after <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>. Univariate analyses were performed using Fisher's exact test for categorical variables. A multivariable model and logistic regression were used to assess the risk factors for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 97 patients in this study. The median duration of follow\u2010up was 1027\u00a0days. Forty\u2010two patients experienced <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation after <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, while 29 (69.0%) experienced reactivation within 1\u00a0year after <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>. The cumulative incidence was 30.7% at 1\u00a0year and 51.2% for the total observation period. Multivariate analysis showed that engraftment after day 10 was an independent risk factor for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed a high incidence of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation in the first year after auto\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">ML<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients. Patients with delayed engraftment are at high risk for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation and should be considered for prolonged <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12406","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T16:40:56Z","timestamp":1433349656000},"page":"544-550","source":"Crossref","is-referenced-by-count":9,"title":["A Japanese single\u2010hospital observational trial with a retrospective case\u2010control analysis of varicella zoster virus reactivation after autologous peripheral blood stem cell transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Mawatari","sequence":"first","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine Tokyo Japan"},{"name":"Division of Hematology Nishigunma National Hospital Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Isoda","sequence":"additional","affiliation":[{"name":"Division of Hematology Nishigunma National Hospital Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Division of Hematology Nishigunma National Hospital Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Division of Hematology Nishigunma National Hospital Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Hematology Nishigunma National Hospital Gunma 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