{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:05:47Z","timestamp":1763017547446},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23591423"],"award-info":[{"award-number":["23591423"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fluoroquinolones are widely used for antibacterial prophylaxis during neutropenia following hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Nevertheless, data are inadequate as to whether fluoroquinolones decrease mortality rate compared with other antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively compared the efficacy of antibacterial prophylaxis using non\u2010absorbable polymyxin B (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0106) or systemic levofloxacin (<jats:styled-content style=\"fixed-case\">LVFX<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0140) after allogeneic <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> at our institute between 2004 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was observed between the 2 groups in the cumulative incidences of failure of prophylaxis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.21), clinically documented infections (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.70), or non\u2010relapse mortality within the first 100\u00a0days after transplantation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.42). With bacteremia, the rate of resistance to <jats:styled-content style=\"fixed-case\">LVFX<\/jats:styled-content> was 82% in the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> group and 100% in the <jats:styled-content style=\"fixed-case\">LVFX<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.41). Also, no significant difference was found in overall survival between the 2 groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate no difference in the effectiveness of antibacterial prophylaxis between systemic antibiotic <jats:styled-content style=\"fixed-case\">LVFX<\/jats:styled-content> and non\u2010absorbable antibiotic <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12416","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T07:09:37Z","timestamp":1435820977000},"page":"647-654","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of antibacterial prophylaxis with non\u2010absorbable polymyxin B compared to levofloxacin after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"S.","family":"Koh","sequence":"first","affiliation":[{"name":"Hematology Graduate School of Medicine Osaka City University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Infection Control Science Graduate School of Medicine Osaka City University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Hematology Graduate School of Medicine Osaka City University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Hematology Graduate School of Medicine Osaka City University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Koh","sequence":"additional","affiliation":[{"name":"Hematology Graduate 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