{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:31:22Z","timestamp":1791311482190,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) is a common complication after hematopoietic allogeneic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) associated with intensity of the conditioning regimen, cyclophosphamide (Cy) therapy, and <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> polyomavirus (<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 33 consecutive haploidentical (haplo) <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients transplanted for hematologic diseases. Eleven patients had a previous transplant. Median follow\u2010up was 11 months. Graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) prophylaxis consisted of cyclosporine + mycophenolate mofetil and post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> Cy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two of 33 patients achieved neutrophil recovery. Cumulative incidence (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of platelet recovery was 65%. <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> acute <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> was 44%. Twenty patients developed <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> in a median time of 38 days. <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> at day 180 was 62%. <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV was positive in blood and urine of 91% of patients at <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> onset. <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> resolved in 18\/20 patients. Factors associated with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> were previous transplant (<jats:italic>P<\/jats:italic> = 0.01) and occurrence of cytomegalovirus reactivation before <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.05). Grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> acute <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> was not associated with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.62). <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> of day 180 viral infections was 73%. Two\u2010year overall survival (OS) was 50%; <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> did not impact <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> after haplo with post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> Cy is high and is associated with morbidity, especially in high\u2010risk patients such as those with a previous transplant history and with impaired immune reconstitution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12455","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T13:38:43Z","timestamp":1441892323000},"page":"822-830","source":"Crossref","is-referenced-by-count":85,"title":["Incidence and risk factors for hemorrhagic cystitis in unmanipulated haploidentical transplant recipients"],"prefix":"10.1111","volume":"17","author":[{"given":"A.","family":"Ruggeri","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"},{"name":"INSERM UMRs 938 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Roth\u2010Guepin","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"},{"name":"Service d'H\u00e9matologie CHU Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Battipaglia","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"},{"name":"Ematologia Universit\u00e0 Federico II di Napoli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010C.","family":"Mamez","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Malard","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"},{"name":"INSERM UMRs 938 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Brissot","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire H\u00f4pital Saint Antoine, AP\u2010HP Paris France"},{"name":"INSERM UMRs 938 Paris France"},{"name":"Universit\u00e9 Pierre &amp; 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