{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:47:11Z","timestamp":1780411631620,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Desensitization (<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content>) with intravenous immunoglobulin (<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>)\u00a0+\u00a0rituximab is effective, safe, and increases the transplantation rate in human leukocyte antigen\u2010sensitized patients. However, reports of progressive multifocal leukoencephalopathy (<jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content>) caused by <jats:styled-content style=\"fixed-case\">JC<\/jats:styled-content> polyomavirus (<jats:styled-content style=\"fixed-case\">JCP<\/jats:styled-content>yV) in autoimmune patients treated with rituximab is concerning. Here, we report on the <jats:styled-content style=\"fixed-case\">JCP<\/jats:styled-content>yV viremia and <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content> status in kidney transplant patients with\/without <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> (non\u2010<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total 1195 and 699 <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples from plasma in 117 <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> (78% lymphocyte\u2010depleting [LyD] induction) and 100 non\u2010<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients (45% LyD), respectively, were submitted for <jats:styled-content style=\"fixed-case\">JCP<\/jats:styled-content>yV\u2010polymerase chain reaction. Results were compared in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No patients in either <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> or non\u2010<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> developed <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content> or presented with any neurological symptoms. The <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content> viremia rate was similar in <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients (3\/117 vs. 9\/100, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). The <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content> levels were low (median peak levels, 1025 copies\/mL) and <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content> viremia was observed only once during the study period in most patients. All 3 <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content>(+) received 1 dose rituximab and no <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients with &gt;1 dose rituximab showed <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content>(+). All 3 <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content>(+) <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients received LyD induction, while only 2 of 9 <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content>(+) non\u2010<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients did so, and the remaining 7 received non\u2010LyD or no induction. <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content> in leukocyte was mostly negative in <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> patients. Immunosuppression in patients with or without <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content>(+) was similar. <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> polyomavirus viremia was observed more commonly in patients with <jats:styled-content style=\"fixed-case\">JCPyV<\/jats:styled-content>(+) than in those without (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\u00a0+\u00a0rituximab <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> followed by transplantation with LyD induction and additional rituximab rarely show <jats:styled-content style=\"fixed-case\">JCP<\/jats:styled-content>yV viremia and appear at low risk for <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12465","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T14:11:10Z","timestamp":1444054270000},"page":"838-847","source":"Crossref","is-referenced-by-count":14,"title":["<scp>JC<\/scp> polyomavirus viremia and progressive multifocal leukoencephalopathy in human leukocyte antigen\u2010sensitized kidney transplant recipients desensitized with intravenous immunoglobulin and rituximab"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Toyoda","sequence":"first","affiliation":[{"name":"Transplant Immunology Laboratory Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kahwaji","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mirocha","sequence":"additional","affiliation":[{"name":"Biostatistics Core Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chu","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vo","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Suviolahti","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ge","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/TRRM.S6359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707894"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000064"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.18"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-186999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22128"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100012105"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/926391"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70226-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0080-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34468"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24906"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.193"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.1.6.9884"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000437671.78716.f3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03710411"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000269706.59977.a5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000165110.78397.93"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318270f322"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.11.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/653823"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/515305"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22408"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.99"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02506-10"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(97)00158-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2010.11.006"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01641.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828c2fa1"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-013-0167-9"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9496-y"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21493"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir507"},{"key":"e_1_2_7_37_1","article-title":"JC virus urinary excretion and seroprevalence in natalizumab\u2010treated multiple sclerosis patients","author":"Delbue S","year":"2014","journal-title":"J Neurovirol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20442"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21951"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02499.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000234837.02126.70"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1309\/23YGPB1E758ECCFP"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP74123"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199903270-00022"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181daaaf1"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.08.006"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12465","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:15:10Z","timestamp":1695482110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/tid.12465"],"URL":"https:\/\/doi.org\/10.1111\/tid.12465","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}