{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:40:52Z","timestamp":1768678852719,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurately identifying latent tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) infection (<jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content>) in liver and renal transplant candidates is important because of the risks associated with both treatment of<jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content>and reactivation of disease in this population. Many programs advocate yearly screening of patients awaiting organ transplantation. The reproducibility of serial interferon\u2010gamma release assay (<jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content>) testing in transplant candidates has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective longitudinal study of patients listed for liver or kidney transplantation between January 1, 2005 and February 1, 2012 at the University of Illinois Medical Center at Chicago. Data collected included demographics, transplant type,<jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content>results, treatment received, and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population was comprised of 795 adults; 79 (10%) had at least 1 indeterminate result; indeterminate results were less common in men (<jats:italic>P<\/jats:italic>= 0.01) and more common in liver transplant candidates (<jats:italic>P<\/jats:italic>&lt; 0.001). The reversion frequency was 27% with a rate of 158.1 reversions in 1000 person\u2010years. A higher magnitude of initial<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>response values was predictive of consistently positive results (<jats:italic>P<\/jats:italic>&lt; 0.001). The conversion frequency was 15% with a rate of 82.6 conversions in 1000 person\u2010years. Among those who converted, the values of the<jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content>varied, with 48% having a<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>response of &lt;1 IU\/mL, 41% 1\u20135 IU\/mL, and only 10% &gt;5 IU\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant number of conversions and reversions occur during serial<jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content>testing of transplant candidates. Delineating true\u2010positive converters from false\u2010positives is an issue that warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12489","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T13:43:08Z","timestamp":1450186988000},"page":"14-21","source":"Crossref","is-referenced-by-count":21,"title":["Serial testing for latent tuberculosis infection in transplant candidates: a retrospective review"],"prefix":"10.1111","volume":"18","author":[{"given":"P.J.","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Medicine Greenville Health System Greenville South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Grim","sequence":"additional","affiliation":[{"name":"Department of Medicine Loyola University Medical Center Maywood Illinois USA"},{"name":"Department of Pharmacy Practice University of Illinois at Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gallitano","sequence":"additional","affiliation":[{"name":"SUNY Downstate Medical Center Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Loyola University Chicago Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medicine Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Layden","sequence":"additional","affiliation":[{"name":"Department of Medicine Loyola University Medical Center Maywood Illinois USA"},{"name":"Department of Public Health Sciences Loyola University Chicago Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit488"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12100"},{"issue":"10","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.20452\/pamw.985","article-title":"How should we treat tuberculosis in adult patients with chronic kidney disease? 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