{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:01:38Z","timestamp":1759482098045,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fungal infection is a common cause of mortality and morbidity in lung transplant recipients (Lu<jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content>). Treatment failure to first\u2010line antifungals because of resistance or intolerance is an increasing problem. Posaconazole (<jats:styled-content style=\"fixed-case\">PCZ<\/jats:styled-content>), a triazole antifungal, is an attractive treatment option.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center retrospective study to describe the use, tolerability, efficacy, and drug interaction effect (with tacrolimus) of <jats:styled-content style=\"fixed-case\">PCZ<\/jats:styled-content> oral suspension in Lu<jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight patients were treated with <jats:styled-content style=\"fixed-case\">PCZ<\/jats:styled-content> oral suspension for prophylaxis (<jats:italic>n<\/jats:italic> = 15), pre\u2010emptive treatment (<jats:italic>n<\/jats:italic> = 31), and treatment of possible (<jats:italic>n<\/jats:italic> = 7) and probable (<jats:italic>n<\/jats:italic> = 25) invasive fungal infection. A range of fungal isolates was encountered. Resolution was observed in 52.4% (probable, possible, and pre\u2010emptive treatment groups). Aggregate all\u2010cause 1\u2010year mortality was 12.8%. <jats:styled-content style=\"fixed-case\">PCZ<\/jats:styled-content> was well tolerated with 11.5% of patients experiencing adverse effects. Despite dose adjustment strategies, 11.7% of patients experienced supratherapeutic tacrolimus levels, which in 5 cases was associated with a rise (mean 21.6 \u03bcmol\/L) in serum creatinine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PCZ<\/jats:styled-content> is well tolerated and appears effective in the management of fungal infection after lung transplantation. Patients receiving concurrent tacrolimus require careful therapeutic drug monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12497","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T13:48:01Z","timestamp":1453211281000},"page":"302-308","source":"Crossref","is-referenced-by-count":15,"title":["Posaconazole in lung transplant recipients: use, tolerability, and efficacy"],"prefix":"10.1111","volume":"18","author":[{"given":"C.L.","family":"Robinson","sequence":"first","affiliation":[{"name":"Toowoomba Base Hospital Toowoomba Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chau","sequence":"additional","affiliation":[{"name":"School of Pharmacy The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.T.","family":"Yerkovich","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane 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