{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T10:54:51Z","timestamp":1775991291961,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) is a great challenge in kidney transplantation, and is often associated with high morbidity and mortality. The aim of this study was to evaluate the epidemiology, clinical manifestations, and impact of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in kidney transplant (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of a cohort of adult <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients from 2000 to 2012, with follow\u2010up until July 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 1737 <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> recipients evaluated, 60 developed <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>: a 5% cumulative incidence, and an incidence rate of 589.4 cases\/100,000 patient\u2010years. Median time to diagnosis was 13.4 months, with 40% of the cases occurring in the first year. New\u2010onset diabetes was significantly associated with post\u2010transplant <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.018). Pulmonary <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> represented 78% of the cases, including disseminated disease. Two patients received latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> treatment and developed active infection. <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> was associated with a significant reduction in patient and graft survival (74% vs. 90.2% in 5 years for patient survival, <jats:italic>P<\/jats:italic> = 0.001; and 58.6% vs. 80.2% in 5 years for graft survival, <jats:italic>P<\/jats:italic> &lt; 0.001). Death and graft loss occurred in the first 6 months after diagnosis in one\u2010third of the patients, 38.8% of them with disseminated disease. Disseminated disease was significantly associated with mortality compared to local disease (41.8% vs. 9.7%, <jats:italic>P<\/jats:italic> = 0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> continues to be a great challenge in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>, especially in developing countries, with significant impact on patient and graft survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12501","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T14:46:45Z","timestamp":1453992405000},"page":"176-182","source":"Crossref","is-referenced-by-count":34,"title":["Epidemiology of tuberculosis after kidney transplantation in a developing country"],"prefix":"10.1111","volume":"18","author":[{"given":"G.","family":"Meinerz","sequence":"first","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"},{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.K.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"},{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Goldani","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"},{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.D.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Keitel","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"},{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03686.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04205.x"},{"key":"e_1_2_6_5_1","unstructured":"WHO.Global tuberculosis report 2014. 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