{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:43:09Z","timestamp":1784194989577,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:00:00Z","timestamp":1460592000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Intestinal and multivisceral transplantation can be complicated by cytomegalovirus (CMV<\/jats:styled-content>)\u2010related viremia and disease. Intravenous ganciclovir (GCV<\/jats:styled-content>) and oral valganciclovir remain the treatment of choice in this setting. Limited data are available on GCV<\/jats:styled-content>\u2010resistant (GCV<\/jats:styled-content>\u2010R) CMV<\/jats:styled-content> infection in small intestine and multivisceral transplant recipients.<\/jats:p><\/jats:sec>Method<\/jats:title>A retrospective review was performed on all patients who underwent small intestine or multivisceral transplantation from November 8, 2003 through November 30, 2008. Those with CMV<\/jats:styled-content> viremia and invasive disease were identified. GCV<\/jats:styled-content> resistance was suspected in patients who continued to have viremic episodes or invasive disease despite appropriate GCV<\/jats:styled-content> treatment. Genotypic analyses were performed to detect the presence of GCV<\/jats:styled-content> resistance genes UL<\/jats:styled-content>97 and UL<\/jats:styled-content>54.<\/jats:p><\/jats:sec>Results<\/jats:title>During the study period, 88 small intestine or multivisceral transplants were performed on 85 patients. Of the 88 transplantations, 16 patients developed CMV<\/jats:styled-content> viremia with or without end\u2010organ disease (18.2%) and 5.7% developed GCV<\/jats:styled-content>\u2010R CMV<\/jats:styled-content> infection. In patients diagnosed with CMV<\/jats:styled-content> infection, 31.3% (5\/16) had GCV<\/jats:styled-content>\u2010R CMV<\/jats:styled-content> infection. Of patients with GCV<\/jats:styled-content>\u2010R CMV<\/jats:styled-content> infection, 80% (4\/5) developed CMV<\/jats:styled-content> allograft enteritis, resulting in allograft explantation in 3 patients. All patients with GCV<\/jats:styled-content>\u2010R CMV<\/jats:styled-content> infection were CMV<\/jats:styled-content> donor positive\/recipient negative. Patients with tissue\u2010invasive CMV<\/jats:styled-content> disease were 18 times more likely to be infected with GCV<\/jats:styled-content>\u2010R CMV<\/jats:styled-content> (95% confidence interval 1.24\u2013260.93; P<\/jats:italic>\u2010value 0.0341).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Small intestinal and multivisceral transplant recipients have a higher rate of GCV<\/jats:styled-content>\u2010R CMV<\/jats:styled-content> infection compared with other solid organ transplant recipients, which is often associated with tissue\u2010invasive disease and allograft loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12507","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T11:43:11Z","timestamp":1454931791000},"page":"202-209","source":"Crossref","is-referenced-by-count":28,"title":["Resistant cytomegalovirus in intestinal and multivisceral transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"J.G.","family":"Timpone","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Travel Medicine Department of Medicine MedStar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yimen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Lenox Hill Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cox","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Travel Medicine Department of Medicine MedStar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Teran","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Travel Medicine Department of Medicine MedStar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ajluni","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Travel Medicine Department of Medicine MedStar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Infectious Diseases Whitman\u2010Walker Clinic Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Department of Surgery MedStar Georgetown University Hospital MedStar Georgetown Transplant Institute Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.N.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Travel Medicine Department of Medicine MedStar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Surgery MedStar Georgetown University Hospital MedStar Georgetown Transplant Institute Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.02.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064928"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.02.005"},{"issue":"5","key":"e_1_2_6_5_1","first-page":"2761","article-title":"Infectious complications after small bowel transplantation in adults: an update","volume":"28","author":"Kusne S","year":"1996","journal-title":"Transplant Proc"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01628.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199504150-00016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328307c7b4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2005.00112.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.873-883.2005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/342844"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/338143"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00463-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02607-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.t01-1-02008.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.09.012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/519941"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31821fad25"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00761.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/342385"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199202010-00020"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2782-2783.2004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.038521"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.10.116"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200202150-00008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200503173521125"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:47:24Z","timestamp":1695574044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/tid.12507"],"URL":"https:\/\/doi.org\/10.1111\/tid.12507","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}