{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:36:02Z","timestamp":1793082962870,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:00:00Z","timestamp":1460592000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Urinary tract infection caused by human adenovirus (HA<\/jats:styled-content>dV) after renal transplantation (RT<\/jats:styled-content>) results in graft loss because of concomitant nephropathy and acute rejection and may result in death because of systemic dissemination.<\/jats:p><\/jats:sec>Methods<\/jats:title>We assessed the time period between RT<\/jats:styled-content> and disease onset, symptoms, treatment details, disease duration, renal graft function, outcomes, and complications.<\/jats:p><\/jats:sec>Results<\/jats:title>HA<\/jats:styled-content>dV infection of the urinary tract occurred in 8 of 170 renal transplant recipients. Symptoms were macrohematuria in all 8 patients, dysuria in 7, and fever in 5. The median period from RT<\/jats:styled-content> to disease onset was 367 (range, 7\u20131763) days, and the median disease duration was 15 (range, 8\u201342) days. The mean serum creatinine (sC<\/jats:styled-content>r) level prior to onset was 1.35\u00a0\u00b1\u00a00.48\u00a0mg\/dL and the mean maximum sC<\/jats:styled-content>r level during disease was 2.34\u00a0\u00b1\u00a01.95\u00a0mg\/dL. These values were increased by \u226525% in 5 patients. The mean sC<\/jats:styled-content>r levels when symptoms resolved was 1.54\u00a0\u00b1\u00a00.67\u00a0mg\/dL, and no significant difference was seen before, during, or after disease onset (P<\/jats:italic>\u00a0=\u00a00.069). Two patients were diagnosed with HA<\/jats:styled-content>dV viremia and 1 with acute tubulointerstitial nephritis revealed on biopsy. In addition to a reduction in immunosuppressant dosage, 2 patients received gammaglobulins and 5 received ganciclovir.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Symptoms of all patients were alleviated, although some patients developed nephritis or viremia. Hence, the possibility of exacerbation should always be considered. Adequate follow\u2010up observation should be conducted, and diligent and aggressive therapeutic intervention is required to prevent the condition from worsening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12519","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T16:10:04Z","timestamp":1456503004000},"page":"234-239","source":"Crossref","is-referenced-by-count":25,"title":["Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation"],"prefix":"10.1111","volume":"18","author":[{"given":"K.","family":"Nanmoku","sequence":"first","affiliation":[{"name":"Surgical Branch Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Surgical Branch Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"Surgical Branch Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Surgical Branch Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kimura","sequence":"additional","affiliation":[{"name":"Surgical Branch Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Miki","sequence":"additional","affiliation":[{"name":"Surgical Branch Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke 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necrotizing adenovirus tubulointerstitial nephritis in a kidney transplant recipient","volume":"2013","author":"Parasuraman R","year":"2013","journal-title":"Case Rep Transplant"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(89)95214-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700997"},{"issue":"2","key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/135965350501000204","article-title":"In vitro susceptibility of adenovirus to antiviral drugs is species\u2010dependent","volume":"10","author":"Morfin F","year":"2005","journal-title":"Antivir Ther"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.007"}],"container-title":["Transplant Infectious 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