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Seventy\u2010two hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>)\u2010infected liver transplant patients and 10 recipients in whom <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> was eradicated before transplantation were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of all biomarkers were significantly higher in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected recipients than in controls. Among <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> recipients, levels of biomarkers were significantly higher in patients with severe recurrence. Although there were no statistically significant differences between biomarkers, <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ELF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 obtained the highest area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve values. The combination of serum biomarkers with Fibroscan increased the negative and positive predictive values, although diagnostic accuracy of individual tests was not significantly improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients at higher risk of severe <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> recurrence can be identified early, 6 months after transplantation, using readily available non\u2010invasive methods.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12526","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:50:57Z","timestamp":1458348657000},"page":"471-479","source":"Crossref","is-referenced-by-count":16,"title":["Early non\u2010invasive selection of patients at high risk of severe hepatitis C recurrence after liver transplantation"],"prefix":"10.1111","volume":"18","author":[{"given":"G.","family":"Crespo","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gambato","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Casals","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Londo\u00f1o","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Forns","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Clinic IDIBAPS and CIBERehd University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Brunet","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics Hospital Clinic IDIBAPS and CIBERehd University of 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