{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:29:06Z","timestamp":1777570146495,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["15346"],"award-info":[{"award-number":["15346"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The polysaccharide cell wall component, 1,3\u2010beta\u2010D\u2010glucan (<jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content>), is used as a serum biomarker for invasive fungal infection (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>). Patients receiving hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) are considered a highly vulnerable group for <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> development. We evaluated the diagnostic performance of serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> screening in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients were prospectively enrolled in this study between September 2014 and August 2015. Routine serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> screening was performed 2\u20133 times weekly by using the Fungitell<jats:sup>\u00ae<\/jats:sup> assay. All samples were classified according to the 2008 <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> criteria, with serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> results not being considered for classification. The diagnostic performance of <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> testing for <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> was calculated. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> values \u226580 pg\/mL were considered positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 308 serum samples were collected in 45 patients. The majority of 172 samples (55.8%) were obtained at the early phase (within 30 days) after allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> levels were significantly higher in 16 possible\/probable <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> samples when compared to no evidence for <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> samples (median 170 pg\/mL, <jats:styled-content style=\"fixed-case\">interquartile range [IQR<\/jats:styled-content>] 100\u2013274 pg\/mL vs. median 15 pg\/mL, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 15\u201315 pg\/mL; <jats:italic>P<\/jats:italic> &lt; 0.001, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test). Diagnostic performance of serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> screening for possible <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\/probable invasive pulmonary aspergillosis vs. no evidence for <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> was as follows: sensitivity 81%, specificity 98%, positive predictive value 65%, negative predictive value (<jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) 99%, and diagnostic odds ratio 176 (95% confidence interval 41\u2013761).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> testing in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients may be highly specific and associated with a very high <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of &gt;99%. Therefore, serum <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> may be a helpful tool to rule out <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12527","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:12:21Z","timestamp":1458349941000},"page":"466-470","source":"Crossref","is-referenced-by-count":21,"title":["Diagnostic performance of 1,3\u2010beta\u2010D\u2010glucan serum screening in patients receiving hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"18","author":[{"given":"F.M.J.","family":"Reischies","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Prattes","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"},{"name":"Center for Biomarker Research in Medicine Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Woelfler","sequence":"additional","affiliation":[{"name":"Division of Hematology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eigl","sequence":"additional","affiliation":[{"name":"Division of Pulmonology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hoenigl","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria"},{"name":"Center for Biomarker Research in Medicine Graz Austria"},{"name":"Division of Pulmonology Medical University of Graz Graz Austria"},{"name":"Division of Infectious Diseases Department of Medicine University of California\u2013San Diego San Diego CA 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