{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:12:57Z","timestamp":1759011177270},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary invasive aspergillosis (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) is a major clinical problem in patients undergoing allogeneic hematopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Acquisition of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> during allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> by inhalation of spores is the rationale for the widespread use of air filtration systems. Recent data suggest that activation of fungal growth in already colonized patients is a relevant factor, and a recent study found a positive correlation of serum immunoglobulin responses against purified recombinant <jats:italic>Aspergillus fumigatus<\/jats:italic> proteins before allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> with the incidence of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate the clinical utility of this approach, we performed a prospective study. We used a commercially available and standardized assay for detection of anti\u2010<jats:italic>Aspergillus<\/jats:italic> immunoglobulin\u2010G (<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>\u2010IgG) in serum (Platelia<jats:sup>\u2122<\/jats:sup> <jats:italic>Aspergillus<\/jats:italic> IgG) that has previously demonstrated high sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a cohort of 104 allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients, we measured <jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>\u2010IgG and <jats:italic>Aspergillus<\/jats:italic> antigen serum levels before allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, and weekly during hospital stay. Overall prevalence of possible, probable, and proven <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> during hospital stay was 10%, 6%, and 0%. We found no correlation between <jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>\u2010IgG levels before allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, or after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, and the prevalence of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> during hospital stay. Furthermore, median <jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>\u2010IgG levels did not differ between patients with history of probable or proven <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>, as compared to patients without history of IA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, our data argue against the clinical utility of measuring <jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>\u2010IgG levels for diagnosis or prediction of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in patients undergoing allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12529","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T03:34:27Z","timestamp":1458617667000},"page":"354-360","source":"Crossref","is-referenced-by-count":7,"title":["Anti\u2010<i>Aspergillus<\/i> immunoglobulin\u2010G testing in serum of hematopoietic stem cell transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"J.\u2010H.","family":"Erdmann","sequence":"first","affiliation":[{"name":"Pharmacy Charit\u00e9 University Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Graf","sequence":"additional","affiliation":[{"name":"Labor Berlin \u2013 Charit\u00e9 Vivantes GmbH Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.W.","family":"Blau","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor immunology Charit\u00e9 University Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor immunology Charit\u00e9 University Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Timm","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor immunology Charit\u00e9 University Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hemmati","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor immunology Charit\u00e9 University Medical School Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor immunology Charit\u00e9 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