{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:52:40Z","timestamp":1791874360606,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010LABX\u20100021"],"award-info":[{"award-number":["ANR\u201011\u2010LABX\u20100021"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n End\u2010stage renal disease (\n ESRD<\/jats:styled-content>\n ) is associated with premature aging of the T\u2010cell system. Nevertheless, the clinical significance of pre\u2010transplant\n ESRD<\/jats:styled-content>\n \u2010related immune senescence is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We studied whether immune risk phenotype (\n IRP<\/jats:styled-content>\n ), a typical feature of immune senescence, may affect post\u2010transplant infectious complications. A total of 486 patients were prospectively studied during the first year post transplant.\n IRP<\/jats:styled-content>\n was defined as positive cytomegalovirus serology with at least 1 of the following criteria:\n CD<\/jats:styled-content>\n 4\/\n CD<\/jats:styled-content>\n 8 ratio <1 and\/or\n CD<\/jats:styled-content>\n 8 T\u2010cell count >90th percentile.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found that 47 patients (9.7%) had pre\u2010transplant\n IRP<\/jats:styled-content>\n .\n IRP<\/jats:styled-content>\n + patients did not differ from\n IRP<\/jats:styled-content>\n \u2212 patients for any clinical characteristics, but exhibited more pronounced immune senescence. Both opportunistic infections (43% vs. 6%,\n P<\/jats:italic>\n < 0.001) and severe bacterial infection (\n SBI<\/jats:styled-content>\n ) (40% vs. 25%,\n P<\/jats:italic>\n = 0.028) were more frequent in\n IRP<\/jats:styled-content>\n +<\/jats:sup>\n patients. In multivariate analysis,\n IRP<\/jats:styled-content>\n was predictive of both opportunistic infection (hazard ratio [\n HR<\/jats:styled-content>\n ] 2.97 [95% confidence interval {\n CI<\/jats:styled-content>\n } 1.53\u20135.76],\n P<\/jats:italic>\n = 0.001), and\n SBI<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 2.33 [95%\n CI<\/jats:styled-content>\n 1.34\u20133.92],\n P<\/jats:italic>\n = 0.008). Acute rejection rates were numerically much lower in\n IRP<\/jats:styled-content>\n + patients. A total of 418 patients (86%) had biological evaluation 1 year post transplant. Among 41\n IRP<\/jats:styled-content>\n + patients, 35 (85%) remained\n IRP<\/jats:styled-content>\n + 1 year post transplant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Pre\u2010transplant\n IRP<\/jats:styled-content>\n is associated with an increased risk of post\u2010transplant infection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12534","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T19:49:36Z","timestamp":1459367376000},"page":"415-422","source":"Crossref","is-referenced-by-count":40,"title":["Pre\u2010transplant end\u2010stage renal disease\u2010related immune risk profile in kidney transplant recipients predicts post\u2010transplant infections"],"prefix":"10.1111","volume":"18","author":[{"given":"T.","family":"Crepin","sequence":"first","affiliation":[{"name":"INSERM UMR1098 Federation Hospitalo\u2010Universitaire INCREASE Besan\u00e7on France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Structure F\u00e9d\u00e9rative de Recherche SFR FED4234 Besan\u00e7on France"},{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gaiffe","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Besan\u00e7on Besan\u00e7on France"},{"name":"CIC Bioth\u00e9rapie INSERM CIC1431 CHU Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Courivaud","sequence":"additional","affiliation":[{"name":"INSERM UMR1098 Federation Hospitalo\u2010Universitaire INCREASE Besan\u00e7on France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Structure F\u00e9d\u00e9rative de Recherche SFR FED4234 Besan\u00e7on France"},{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roubiou","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Structure F\u00e9d\u00e9rative de Recherche SFR FED4234 Besan\u00e7on France"},{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Laheurte","sequence":"additional","affiliation":[{"name":"INSERM UMR1098 Federation Hospitalo\u2010Universitaire INCREASE Besan\u00e7on France"},{"name":"Plateforme de Biomonitoring EFS Bourgogne Franche\u2010Comt\u00e9 CIC 1431\/UMR1098 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Moulin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Frimat","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rieu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Reims Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mousson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Durrbach","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Kremlin\u2010Bic\u00eatre Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010E.","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Clermont\u2010Ferrand Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Saas","sequence":"additional","affiliation":[{"name":"INSERM UMR1098 Federation Hospitalo\u2010Universitaire INCREASE Besan\u00e7on France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Structure F\u00e9d\u00e9rative de Recherche SFR FED4234 Besan\u00e7on France"},{"name":"CIC Bioth\u00e9rapie INSERM CIC1431 CHU Besan\u00e7on Besan\u00e7on France"},{"name":"Plateforme de Biomonitoring EFS Bourgogne Franche\u2010Comt\u00e9 CIC 1431\/UMR1098 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bamoulid","sequence":"additional","affiliation":[{"name":"INSERM UMR1098 Federation Hospitalo\u2010Universitaire INCREASE Besan\u00e7on France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Structure F\u00e9d\u00e9rative de Recherche SFR FED4234 Besan\u00e7on France"},{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ducloux","sequence":"additional","affiliation":[{"name":"INSERM UMR1098 Federation Hospitalo\u2010Universitaire INCREASE Besan\u00e7on France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Structure F\u00e9d\u00e9rative de Recherche SFR FED4234 Besan\u00e7on France"},{"name":"Department of Nephrology, Dialysis, and Renal Transplantation CHU Besan\u00e7on Besan\u00e7on France"},{"name":"CIC Bioth\u00e9rapie INSERM CIC1431 CHU Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13092"},{"key":"e_1_2_6_4_1","first-page":"440","article-title":"Decline in mitogen induced proliferation of lymphocytes with increasing age","volume":"70","author":"Murasko DM","year":"1987","journal-title":"Clin Exp 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Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12534","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:27:36Z","timestamp":1695554856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,21]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/tid.12534"],"URL":"https:\/\/doi.org\/10.1111\/tid.12534","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,21]]}}}