{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:53:38Z","timestamp":1787662418883,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dolutegravir is a preferred antiretroviral drug for human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>)\u2010infected patients following solid organ transplantation. It has potent antiretroviral activity and does not interact with calcineurin inhibitors. We describe a case of an <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected kidney transplant patient, who was noted to have a rising serum creatinine following initiation of dolutegravir. At first, an acute rejection episode was suspected, but this finding was later attributed to inhibition of creatinine secretion by dolutegravir. We suggest that an awareness of this potential effect of dolutegravir is important for providers who take care of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive kidney transplant recipients, in order to prevent potentially unnecessary testing.<\/jats:p>","DOI":"10.1111\/tid.12545","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T14:41:42Z","timestamp":1462804902000},"page":"625-627","source":"Crossref","is-referenced-by-count":14,"title":["Serum creatinine elevation after switch to dolutegravir in a human immunodeficiency virus\u2013positive kidney transplant recipient"],"prefix":"10.1111","volume":"18","author":[{"given":"D.H.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Drexel University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.E.","family":"Malat","sequence":"additional","affiliation":[{"name":"Department of Surgery Drexel University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"Bias","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Drexel University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.N.","family":"Harhay","sequence":"additional","affiliation":[{"name":"Division of Nephrology Drexel University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ranganna","sequence":"additional","affiliation":[{"name":"Division of Nephrology Drexel University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Division of Nephrology Drexel University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070726"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13220"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13344"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02778.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01098.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182734651"},{"issue":"4","key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"19490","DOI":"10.7448\/IAS.17.4.19490","article-title":"Once\u2010daily dolutegravir is superior to once\u2010daily darunavir\/ritonavir in treatment\u2010naive HIV\u20101\u2010positive individuals: 96 week results from FLAMINGO","volume":"17","author":"Molina JM","year":"2014","journal-title":"J Int AIDS Soc"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215541"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70257-3"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283612419"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182645648"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04440.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.66"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.07.008"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.146225"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12545","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:08:02Z","timestamp":1695568082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,20]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/tid.12545"],"URL":"https:\/\/doi.org\/10.1111\/tid.12545","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,20]]}}}