{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:44:08Z","timestamp":1790786648701,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["13\/00045"],"award-info":[{"award-number":["13\/00045"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM13\/00180"],"award-info":[{"award-number":["CM13\/00180"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR14\/00036"],"award-info":[{"award-number":["JR14\/00036"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibiotic resistance is an emerging phenomenon in kidney transplantation (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared species distribution and antimicrobial susceptibility patterns in 1052 isolates from urine cultures obtained in 2 different cohorts of kidney transplant recipients in a single center (Cohort A: 189 patients undergoing KT between January 2002 and December 2004 [336 isolates]; Cohort B: 115 patients undergoing KT between January 2011 and December 2013 [716 isolates]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asymptomatic bacteriuria accounted for most of the isolates (86.9% in Cohort A and 92.3% in Cohort B). <jats:italic><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lebsiella pneumoniae<\/jats:italic> (9.5% vs. 15.6%), <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas aeruginosa<\/jats:italic> (1.8% vs. 7.9%), and <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nterobacter cloacae<\/jats:italic> (0.6% vs. 3.1%) were significantly more common in Cohort B. The isolation of <jats:italic><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>. pneumoniae<\/jats:italic> in Cohort B was associated with the occurrence of acute pyelonephritis (9.8% of all <jats:italic><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>. pneumoniae<\/jats:italic> isolates vs. 2.8% of the remaining uropathogens; <jats:italic>P<\/jats:italic> = 0.001). Non\u2010susceptibility rates among Enterobacteriaceae in Cohort B were higher for every class of antibiotics (<jats:italic>P<\/jats:italic> \u2264 0.003) with the exception of fosfomycin. Compared to Cohort A, significant increases were seen in isolates from Cohort B for multidrug\u2010resistant (<jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>) (43.9% vs. 67.8%, respectively; <jats:italic>P<\/jats:italic> = 0.001), extended\u2010spectrum beta\u2010lactamase (<jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>)\u2010producing (6.6% vs. 26.1%; <jats:italic>P<\/jats:italic> = 0.001), and carbapenemase\u2010producing Enterobacteriaceae strains (0.0% vs. 5.0%; <jats:italic>P<\/jats:italic> = 0.001). Such differences were mostly attributable to <jats:italic><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>. pneumoniae<\/jats:italic> (as 54.5% and 13.4% of isolates in Cohort B were <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing and carbapenemase\u2010producing, respectively). <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content> isolates were responsible for 69.1% of episodes of symptomatic urinary tract infection in Cohort B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increase in resistance rates among Enterobacteriaceae uropathogens is significant and may have an effect on <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> programs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12547","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T14:23:47Z","timestamp":1463581427000},"page":"575-584","source":"Crossref","is-referenced-by-count":47,"title":["Progressive increase of resistance in Enterobacteriaceae urinary isolates from kidney transplant recipients over the past decade: narrowing of the therapeutic options"],"prefix":"10.1111","volume":"18","author":[{"given":"J.","family":"Orig\u00fcen","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"L\u00f3pez\u2010Medrano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ruiz\u2010Merlo","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fiorante","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) School of Medicine Universidad Complutense Madrid 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