{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:10:35Z","timestamp":1761991835107,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Progressive multifocal leukoencephalopathy (<jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content>) is a demyelinating disease of the central nervous system caused by the <jats:styled-content style=\"fixed-case\">JC<\/jats:styled-content> polyomavirus (<jats:styled-content style=\"fixed-case\">JCP<\/jats:styled-content>yV) in immunocompromised patients, including solid organ transplant recipients. We report 2 cases of <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content> late after liver transplantation (144 and 204\u00a0months) and review the few other published cases. The clinical course of <jats:styled-content style=\"fixed-case\">PML<\/jats:styled-content> is characterized by a rapid progressive neurological decline coinciding with the presence of white matter lesions on magnetic resonance images. No direct antiviral therapy is available against the <jats:styled-content style=\"fixed-case\">JCP<\/jats:styled-content>yV. The prognosis is therefore extremely poor. Restoration of the immune response achieved by tapering or ending the immunosuppressive therapy is the basis of treatment in transplanted patients. One of our patients is alive 3\u00a0years after diagnosis after total withdrawal of immunosuppressive therapy. The other presented severe rejection when tapering immunosuppression and died 26\u00a0months after diagnosis.<\/jats:p>","DOI":"10.1111\/tid.12554","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T19:33:52Z","timestamp":1464204832000},"page":"606-610","source":"Crossref","is-referenced-by-count":5,"title":["Progressive multifocal leukoencephalopathy after liver transplantation can have favorable or unfavorable outcome"],"prefix":"10.1111","volume":"18","author":[{"given":"J.","family":"Dumortier","sequence":"first","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives Hospices civils de Lyon H\u00f4pital Edouard Herriot Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Guillaud","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives Hospices civils de Lyon H\u00f4pital 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