{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:53:20Z","timestamp":1787064800910,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003180","name":"Academisch Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["281156"],"award-info":[{"award-number":["281156"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Solid organ transplant (\n                      <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>\n                      ) recipients are at risk of infections of the central nervous system. However, the incidence and clinical course of bacterial meningitis in\n                      <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>\n                      recipients are unclear. We studied occurrence, disease course, and prognosis of bacterial meningitis in\n                      <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>\n                      recipients in the Netherlands.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with a medical history of solid organ transplantation were selected from our nationwide prospective cohort study on community\u2010acquired bacterial meningitis in patients &gt;16\u00a0years old, performed from March 1, 2006 to October 31, 2014. Data on patient history, symptoms and signs on admission, treatment, and outcome were collected prospectively. For transplant recipients, additional information was collected retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 6\n                      <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>\n                      recipients, all receiving renal transplants. The annual incidence of bacterial meningitis was 7\u2010fold higher (95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 2.94\u201317.02,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) for renal transplant recipients as compared with the general population (9.56 [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      3.98\u201322.96] vs. 1.35 [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.28\u20131.43] per 100,000 patients per year). One of the 6 patients (17%) presented with the classic presentation of bacterial meningitis (fever, neck stiffness, and change in mental status). Seizures were common, occurring in 33% of patients.\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      and\n                      <jats:italic>Listeria monocytogenes<\/jats:italic>\n                      were identified in 2 patients each, and\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      and\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      were both identified once. Four of 6 patients (67%) had an unfavorable functional outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Bacterial meningitis is a rare but devastating complication of solid organ transplantation.\n                      <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>\n                      recipients are at high risk for developing meningitis, and recognition of this condition may be difficult, owing to atypical clinical manifestation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.12570","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T10:37:08Z","timestamp":1467801428000},"page":"674-680","source":"Crossref","is-referenced-by-count":43,"title":["Bacterial meningitis in solid organ transplant recipients: a population\u2010based prospective study"],"prefix":"10.1111","volume":"18","author":[{"given":"K.E.B.","family":"van Veen","sequence":"first","affiliation":[{"name":"Department of Neurology Center of Infection and Immunity Amsterdam (CINIMA) Academic Medical Center University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Neurology Medical Center Haaglanden The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Neurology Center of Infection and Immunity Amsterdam (CINIMA) Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"van der Ende","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Center of Infection and Immunity Amsterdam (CINIMA) Academic Medical Center University of Amsterdam Amsterdam the Netherlands"},{"name":"The Netherlands Reference Laboratory for Bacterial Meningitis Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"van de Beek","sequence":"additional","affiliation":[{"name":"Department of Neurology Center of Infection and Immunity Amsterdam (CINIMA) Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Organ Procurement and Transplantation Network (OPTN).optn.transplant.hrsa.gov. 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