{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T11:10:57Z","timestamp":1696072257072},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data are available on the incidence and characteristics of culture\u2010negative fever following pancreas transplantation (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>x) with anti\u2010thymocyte globulin (<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) induction. Our study aims to better define the features of culture\u2010negative fever, so it can be delineated from infectious fever, hopefully helping clinicians to guide antibiotic therapy in this high\u2010risk patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of postoperative fever among 198 consecutive patients undergoing <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>x at our center between August 1, 2004 and December 31, 2014. Fever was classified as culture\u2010negative if there was neither a positive culture nor a documented clinical diagnosis of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fever was identified in 113 patients; 66 were deemed to be infectious, 39 were culture\u2010negative, and 8 were indeterminate. High body mass index of recipient (odds ratio 1.87, 95% confidence interval: 1.15\u20133.03, <jats:italic>P<\/jats:italic> = 0.011) was a significant factor associated with culture\u2010negative fever in multivariate analysis. No patients with culture\u2010negative fever were diagnosed with infiltrates or effusion on chest radiography. In addition, an increase in white blood cell count, C\u2010reactive protein, and serum amylase was less prominent in culture\u2010negative fever. Culture\u2010negative fever developed most frequently at postoperative 7 or 14 days, showing a biphasic curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Culture\u2010negative fever develops in a substantial proportion of patients early after <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>x. The awareness of the possibility and clinical features of post\u2010transplant culture\u2010negative fever might help clinicians to guide antibiotic therapy in this high\u2010risk patient population, especially following <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> induction and early steroid withdrawal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12572","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T15:56:01Z","timestamp":1467906961000},"page":"681-689","source":"Crossref","is-referenced-by-count":3,"title":["Incidence and differential characteristics of culture\u2010negative fever following pancreas transplantation with anti\u2010thymocyte globulin induction"],"prefix":"10.1111","volume":"18","author":[{"given":"S.","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul 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