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Herpes simplex virus (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>) reactivations are usually prevented by acyclovir (<jats:styled-content style=\"fixed-case\">ACV<\/jats:styled-content>) prophylaxis, whereas cidofovir (<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>) has been used off indication to manage AdV infections. We report a child with myelodysplastic syndrome undergoing multiple <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, who experienced <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101 disease including severe mucositis and herpetic whitlow, as well as high viral load AdV <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>emia. Both <jats:styled-content style=\"fixed-case\">ACV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content> were ineffective; however, viral loads were decreased with brincidofovir, resulting in viral clearance. A subsequent Epstein\u2013Barr virus disease with relevant meningoencephalitis responded to rituximab.<\/jats:p>","DOI":"10.1111\/tid.12582","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T14:17:00Z","timestamp":1470233820000},"page":"791-794","source":"Crossref","is-referenced-by-count":28,"title":["Brincidofovir clearance of acyclovir\u2010resistant herpes simplex virus\u20101 and adenovirus infection after stem cell transplantation"],"prefix":"10.1111","volume":"18","author":[{"given":"S.","family":"Voigt","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Robert Koch Institute Berlin Germany"},{"name":"Department of Pediatric Oncology\/Hematology\/SCT Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology Helmut\u2010Ruska\u2010Haus Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin and Labor Berlin Charit\u00e9\u2010Vivantes GmbH Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Edelmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology Helmut\u2010Ruska\u2010Haus Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin and Labor Berlin Charit\u00e9\u2010Vivantes GmbH Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sauerbrei","sequence":"additional","affiliation":[{"name":"Institute of Virology and Antiviral Therapy German Consulting Laboratory for HSV and VZV Jena University Hospital Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010S.","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology\/SCT Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107093050202"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv285"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00615-10"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/518938"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-014-0416-y"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05983-11"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.948847"},{"issue":"6","key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/QCO.0000000000000211","article-title":"Herpes simplex virus and varicella zoster virus: recent advances in therapy","volume":"28","author":"De SK","year":"2015","journal-title":"Curr Opin Infect Dis"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00545-11"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/656717"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1083975"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.007"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.01.009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705730"},{"key":"e_1_2_5_17_1","first-page":"3121","volume-title":"Thomas\u2019 Hematopoietic Cell Transplantation","author":"Ito JF","year":"2011"},{"key":"e_1_2_5_18_1","unstructured":"FlorescuDF GrimleyMS BourneE et al.Preliminary Data from 13 Liver Transplantation Patients who received Brincidofovir (BCV) for Adenovirus (AdV) Infection. 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