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Recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>i) is of great interest. Although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive therapy in the presence of a viral infection. This review was developed to gather the evidence on antiviral activity of the <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>i against the viruses that most commonly reactivate in adult solid organ recipients: cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>), polyomavirus, Epstein\u2010Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>), human herpesvirus 8 (<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8), and hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>). A <jats:italic>rapid review<\/jats:italic> methodology and evaluation of quality and consistency of evidence based on the <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> system was used. The existing literature was variable in nature, although indicating a potential advantage of <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>i in <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>, polyomavirus, and <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8 infection, and a most doubtful relation with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection. Several recommendations about the management of these infections are presented that can change certain current patterns of immunosuppression and help to improve the prognosis of the direct and indirect effects of viral infection in solid organ recipients.<\/jats:p>","DOI":"10.1111\/tid.12601","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T11:36:14Z","timestamp":1473248174000},"page":"819-831","source":"Crossref","is-referenced-by-count":73,"title":["Role of <scp>mTOR<\/scp> inhibitors for the control of viral infection in solid organ transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"Julio","family":"Pascual","sequence":"first","affiliation":[{"name":"Department of Nephrology Hospital del Mar Barcelona Spain"},{"name":"Institut Mar for Medical Research Barcelona Spain"},{"name":"REDINREN Spanish Network for Renal Research RD12\/0021 Barcelona 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