{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:04:09Z","timestamp":1787313849263,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Although high\u2010dose steroid therapy has been attempted for the management of clinically suspected allograft rejection, before testing for\n BK<\/jats:styled-content>\n viral activity or acute cellular rejection accompanied by\n BK<\/jats:styled-content>\n polyomavirus nephropathy, its long\u2010term outcome remains unknown. We investigated the impact of high\u2010dose steroids on\n BK<\/jats:styled-content>\n viral activity and long\u2010term graft outcomes in patients with\n BK<\/jats:styled-content>\n viremia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study population comprised 144 kidney transplant recipients with\n BK<\/jats:styled-content>\n viremia. They were divided into 2 groups based on the amount of steroids administered: low\u2010dose group (<2\u00a0g,\n n<\/jats:italic>\n =123) or high\u2010dose group (\u22652\u00a0g,\n n<\/jats:italic>\n =21).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The baseline serum\n BK<\/jats:styled-content>\n viral loads were 5.4\u00b11.1 log cp\/mL in the low\u2010dose group and 6.0\u00b11.3 in the high\u2010dose group (\n P<\/jats:italic>\n =.054). These changed to 5.2\u00b11.3 and 6.1\u00b11.4, 1\u00a0month after steroid treatment (\n P<\/jats:italic>\n =.03) and 4.9\u00b11.3 and 5.9\u00b11.4 at 2\u00a0months (\n P<\/jats:italic>\n =.033), respectively. From 3\u00a0months to 1\u00a0year, the serum\n BK<\/jats:styled-content>\n viral titers were not different between groups. Kaplan\u2010Meier analyses demonstrated that the rates of the decline of graft function and graft failure were higher in the high\u2010dose group (\n P<\/jats:italic>\n =.02 and\n P<\/jats:italic>\n =.04, respectively). High\u2010dose steroids (\n P<\/jats:italic>\n =.012, hazard ratio [\n HR<\/jats:styled-content>\n ] 5.04, 95% confidence interval [\n CI<\/jats:styled-content>\n ] 1.42\u201317.85) and log serum\n BK<\/jats:styled-content>\n viral load at 2\u00a0months after steroid treatment (\n P<\/jats:italic>\n =.042,\n HR<\/jats:styled-content>\n 1.52, 95%\n CI<\/jats:styled-content>\n 1.02\u20132.28) were independent risk factors for the decline of graft function.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n High\u2010dose steroids induced\n BK<\/jats:styled-content>\n viral activation and subsequently resulted in poor long\u2010term graft function and early graft failure in patients with\n BK<\/jats:styled-content>\n viremia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12604","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T10:36:49Z","timestamp":1473763009000},"page":"844-849","source":"Crossref","is-referenced-by-count":7,"title":["High\u2010dose steroid therapy in\n BK<\/scp>\n viremia adversely affected the long\u2010term graft function after kidney transplantation"],"prefix":"10.1111","volume":"18","author":[{"given":"Hyosang","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Hee","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duck Jong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Kil","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90608-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020439"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04320.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00770-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1128\/jvi.68.4.2398-2408.1994","article-title":"A steroid hormone response unit in the late leader of the noncoding control region of the human polyomavirus BK confers enhanced host cell permissivity","volume":"68","author":"Moens U","year":"1994","journal-title":"J 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