{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:33:49Z","timestamp":1767904429266,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,12,3]],"date-time":"2016-12-03T00:00:00Z","timestamp":1480723200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Deceased organ donors, where the cause of death is meningitis or encephalitis, are a potential concern because of the risks of transmission of a potentially fatal infection to recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> Transplant Registry, a retrospective cohort analysis of deceased organ donors in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> was undertaken to better understand the extent to which organs from deceased donors with meningitis and\/or encephalitis (M\/E) (of both known and unknown cause) have been used for transplantation, and to determine the associated recipient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2003 and 2015, 258 deceased donors with M\/E were identified and the causative agent was known in 188 (72.9%). These donors provided 899 solid organs for transplantation (455 kidneys and 444 other organs). The only recorded case of disease transmission was from a donor with encephalitis of unknown cause at time of transplantation who transmitted a fatal nematode infection to 2 kidney transplant recipients. A further 3 patients (2 liver and 1 heart recipient) died within 30\u00a0days of transplantation from a neurological cause (cerebrovascular accident) with no suggestion of disease transmission. Overall, patient and graft survival in recipients of organs from donors with M\/E were similar to those for all other types of deceased organ donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Donors dying with M\/E represent a valuable source of organs for transplantation. The risk of disease transmission is low but, where the causative agent is unknown, caution is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12621","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T16:44:29Z","timestamp":1476204269000},"page":"862-871","source":"Crossref","is-referenced-by-count":14,"title":["Transplantation of organs from deceased donors with meningitis and encephalitis: a <scp>UK<\/scp> registry analysis"],"prefix":"10.1111","volume":"18","author":[{"given":"Patrick B.","family":"Trotter","sequence":"first","affiliation":[{"name":"National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU) University of Cambridge  Cambridge UK"},{"name":"NHS Blood and Transplant (NHSBT)  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Robb","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant (NHSBT)  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Hulme","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant (NHSBT)  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-0726","authenticated-orcid":false,"given":"Dominic M.","family":"Summers","sequence":"additional","affiliation":[{"name":"National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU) University of Cambridge  Cambridge UK"},{"name":"NHS Blood and Transplant (NHSBT)  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J. E.","family":"Watson","sequence":"additional","affiliation":[{"name":"National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU) University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Andrew","family":"Bradley","sequence":"additional","affiliation":[{"name":"National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU) University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Neuberger","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant (NHSBT)  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NeubergerJ WatsonC HulmeW.Use of Organs from High Risk Donors. 2014 Nov 20:1\u201322.http:\/\/www.odt.nhs.uk\/pdf\/Use_of_Organs_from_High_Risk_Donors.pdf. 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