{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:53:07Z","timestamp":1790146387845,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH)","award":["UL1TR000448, sub-award TL1TR000449"],"award-info":[{"award-number":["UL1TR000448, sub-award TL1TR000449"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of T\u2010cell replete haploidentical hematopoietic cell transplant (haplo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) has increased substantially since the introduction of post\u2010transplant cyclophosphamide (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>y) regimens. Limited data exist concerning infectious complications of haplo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> utilizing mobilized peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) hematopoietic cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included all adult patients at our institution undergoing <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> haplo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>y between June 2009 and June 2015. Infections were microbiologically confirmed. Invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>) classified as \u201cproven\u201d or \u201cprobable\u201d by standard definitions were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 104 patients were identified. Median follow\u2010up was 218\u00a0days (range: 6\u20131576). A total of 322 episodes of infection were recorded. Eighty\u2010nine percent of patients experienced at least one infection. Median time to first infection was 22\u00a0days. Patients experiencing at least one bacterial, viral, and <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> were 62%, 72%, and 6%, respectively. The majority (69%) of bacterial infections were caused by enteric organisms. Seven cases of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>taphylococcus aureus<\/jats:italic> infection were recorded, with one bacteremia case. Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) viremia occurred in 54\/71 (76%) at\u2010risk patients at a median time of 24\u00a0days. Sixteen (15%) patients developed <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> disease. Nineteen percent (20\/104) of patients developed <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> polyomavirus\u2010associated cystitis. Six (6%) patients experienced a total of seven <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>. Infection was the primary cause of death for 12% (6\/51) of patients and was a secondary cause for 41%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> haplo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> patients, a high incidence of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> viremia and disease was observed. Infections with enteric bacteria were common. Fungal and staphylococcal infections were uncommon. Further studies are needed to compare infectious complications in haplo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> with other transplant modalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12629","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:09:28Z","timestamp":1478534968000},"source":"Crossref","is-referenced-by-count":85,"title":["Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-6644","authenticated-orcid":false,"given":"Michael","family":"Slade","sequence":"first","affiliation":[{"name":"Department of Medicine Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Romee","sequence":"additional","affiliation":[{"name":"Division of Oncology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"DiPersio","sequence":"additional","affiliation":[{"name":"Division of Oncology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik R.","family":"Dubberke","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Westervelt","sequence":"additional","affiliation":[{"name":"Division of Oncology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey L.","family":"Uy","sequence":"additional","affiliation":[{"name":"Division of Oncology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.3523"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-639831"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203517"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12365"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.05.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3380"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.11.044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.3.273"},{"key":"e_1_2_8_16_1","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.2.267.267"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.08.047"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq147"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/339329"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_8_22_1","unstructured":"CordonnierC EngelhardD LjungmanP et\u00a0al.EBMT definitions of infectious diseases and complications after stem cell transplant 2001. 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