{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:16:05Z","timestamp":1770448565648,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007314","name":"Duncan Family Institute for Cancer Prevention and Risk Assessment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>polyomavirus (<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV) infections are known indicators of immune suppression in hematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) recipients; they can lead to hemorrhagic cystitis, ureteral stenosis, renal dysfunction, and prolonged hospital stays. In this study, we determined transplant\u2010associated variables and immune parameters that can predict for the risk of<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV viruria. We hypothesized that<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV infection is a marker of poor immune recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed all engrafted patients undergoing first allogeneic<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>at<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>Anderson Cancer Center in Houston between January 2004 and December 2012. We evaluated their immune parameters and their transplant\u2010associated factors.<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV positivity was defined as<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV detection in urine by polymerase chain reaction testing. Cox proportional hazards model, as well as competing risk analysis method using subdistribution hazard models with death as competing risk, were applied to assess risk of<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV viruria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified a total of 2477 patients with a median age of 52\u00a0years.<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV viruria was manifest in 25% (n=629) of the patients. The median time from transplantation to<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV viruria development was 42\u00a0days among the patients who had<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV viruria. On multivariate analysis, tumor type, acute<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>, chronic<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>, myeloablative conditioning regimen, cord blood as the graft source,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56<jats:sup>+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>counts, and low platelet count were shown to be significantly associated with<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV infection. These finding were further confirmed when models incorporating the competing risk of death yielded similar findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we report significant associations between<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV reactivation following allogeneic<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>and suppressed immune variables. In addition, this study provides valuable information on the immune status of<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>recipients as a predictor of<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV infections that may in turn help us formulate plans for more effective prevention and treatment of this infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12632","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T16:43:52Z","timestamp":1479314632000},"source":"Crossref","is-referenced-by-count":20,"title":["Poor immune reconstitution is associated with symptomatic<scp>BK<\/scp>polyomavirus viruria in allogeneic stem cell transplant recipients"],"prefix":"10.1111","volume":"19","author":[{"given":"Ala","family":"Abudayyeh","sequence":"first","affiliation":[{"name":"Section of Nephrology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Section of Nephrology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maen","family":"Abdelrahim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valda D.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Section of Nephrology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Rondon","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borje S.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimaz","family":"Afrough","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Tarrand","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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