{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:23:18Z","timestamp":1791958998535,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this research paper was to determine the incidence, risk factors, and clinical outcome of solid organ transplant (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) recipients diagnosed and treated for cryptococcosis at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of all patients with <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> diagnosed and treated for cryptococcal infection occurring between January 2001 and December 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 102 patients diagnosed with cryptococcal infection, 23 were <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients. Renal transplant accounted for 22\/23 cases, of which 13 had meningitis. The annual incidence of infection has risen significantly, and is now greater than 2\/1000 prevalent renal transplant recipients. As expected, biochemical factors associated with meningitis include lower glucose on cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) analysis, median 2.4 vs 4.5\u00a0mmol\/L (<jats:italic>P<\/jats:italic>=.02); <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> white blood cell median 50 vs 1\/\u03bcL (<jats:italic>P<\/jats:italic>&lt;.001); <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> protein, median 950 vs 335\u00a0mg\/L (<jats:italic>P<\/jats:italic>=.04). Serum cryptococcal antigen titers were higher in the meningitis cohort, median 512 vs 32 (<jats:italic>P<\/jats:italic>=.03). Clinically, headache on admission (odds ratio: 9 [1.29\u201063.03], <jats:italic>P<\/jats:italic>=.03) and a prolonged length of stay (median of 36 vs 13\u00a0days) in the meningitis cohort (<jats:italic>P<\/jats:italic>=.02) were significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cryptococcal infection in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients remains rare; however, there has been a marked increase in cases since 2014. This study reveals a need for increased vigilance for a potential emerging infectious disease. It furthermore highlights the need for ongoing research to further aid early diagnosis, prognostication, management, and screening cost\u2010effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12639","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T17:22:14Z","timestamp":1479835334000},"source":"Crossref","is-referenced-by-count":36,"title":["Cryptococcal infections in solid organ transplant recipients over a 15\u2010year period at a state transplant center"],"prefix":"10.1111","volume":"19","author":[{"given":"Ian","family":"Gassiep","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"School of Medicine University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McDougall","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Princess Alexandra Hospital  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