{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:17:04Z","timestamp":1762867024442,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report here the successful treatment of hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) transmitted from a nucleic acid testing (<jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content>)\u2010negative donor to three <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010negative recipients\u2014two renal transplants and one liver. Both renal recipients underwent standard deceased\u2010donor renal transplantation with immediate graft function. The liver recipient underwent standard orthotopic liver transplantation and recovered uneventfully. The donor was a 39\u2010year\u2010old woman with a terminal serum creatinine of 0.7\u00a0mg\/dL. She was high risk for bloodborne pathogens, based upon a history of sexual contact with an <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected male partner. Recipient 1 was a 45\u2010year\u2010old man with a history of end\u2010stage renal disease from systemic lupus erythematosus. Recipient 2 was a 62\u2010year\u2010old woman with a history of end\u2010stage renal disease caused by hypertension and insulin\u2010dependent diabetes. Recipient 3 was a 42\u2010year\u2010old man with acute liver failure from acetaminophen ingestion. All recipients became <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> polymerase chain reaction positive on post\u2010transplant follow\u2010up. Both kidney recipients were treated with ledipasvir\/sofosbuvir combination therapy for 12\u00a0weeks without side effects or rejection episodes. Recipient 3 was treated with ledipasvir\/sofosbuvir in combination with ribavirin for 12\u00a0weeks without side effects. All patients achieved a sustained viral response at 12\u00a0weeks and are considered cured of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. The kidney recipients maintained good allograft function with a serum creatinine of 1.4\u00a0mg\/dL and 1.0\u00a0mg\/dL, respectively. Both renal recipients maintained normal liver function post treatment and did not develop any evidence of fibrosis. The liver recipient's liver function tests returned to normal without further incident. This case report provides evidence for the successful treatment of donor\u2010derived <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in transplant recipients.<\/jats:p>","DOI":"10.1111\/tid.12660","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T17:10:08Z","timestamp":1483722608000},"source":"Crossref","is-referenced-by-count":21,"title":["Successful treatment of donor\u2010derived hepatitis C viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens"],"prefix":"10.1111","volume":"19","author":[{"given":"Ashesh P.","family":"Shah","sequence":"first","affiliation":[{"name":"Transplant Division Department of Surgery Thomas Jefferson University  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0253-2970","authenticated-orcid":false,"given":"Pooja","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Nephrology Thomas Jefferson University  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Frank","sequence":"additional","affiliation":[{"name":"Transplant Division Department of Surgery Thomas Jefferson University  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Fenkel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Thomas Jefferson University  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13283"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02782.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03460.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00649.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/315355"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603283341302"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.30113.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20560"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13518"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408921"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13620"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13767"},{"key":"e_1_2_6_14_1","first-page":"S183","volume-title":"Ledipasvir\/Sofosbuvir for 12 or 24 Weeks is Safe and Effective in Kidney Transplant Recipients with Chronic Genotype 1 or 4 HCV Infection","author":"Colombo M","year":"2016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1505074"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800403"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02931.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000034944.90425.75"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13450"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26164"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:03:14Z","timestamp":1695474194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/tid.12660"],"URL":"https:\/\/doi.org\/10.1111\/tid.12660","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2017,2,22]]},"article-number":"e12660"}}