{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:10:36Z","timestamp":1788534636691,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disseminated acanthamoebiasis is a rare, often fatal, infection most commonly affecting immunocompromised patients. We report a case involving sinuses, skin, and bone in a 60\u2010year\u2010old woman 5\u00a0months after heart transplantation. She improved with a combination of flucytosine, fluconazole, miltefosine, and decreased immunosuppression. To our knowledge, this is the first case of successfully treated disseminated acanthamoebiasis in a heart transplant recipient and only the second successful use of miltefosine for this infection among solid organ transplant recipients. <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>canthamoeba<\/jats:italic> infection should be considered in transplant recipients with evidence of skin, central nervous system, and sinus infections that are unresponsive to antibiotics. Miltefosine may represent an effective component of a multidrug therapeutic regimen for the treatment of this amoebic infection.<\/jats:p>","DOI":"10.1111\/tid.12661","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T15:26:09Z","timestamp":1483975569000},"source":"Crossref","is-referenced-by-count":39,"title":["Disseminated <i><scp>A<\/scp>canthamoeba<\/i> infection in a heart transplant recipient treated successfully with a miltefosine\u2010containing regimen: Case report and review of the literature"],"prefix":"10.1111","volume":"19","author":[{"given":"Max N.","family":"Brondfield","sequence":"first","affiliation":[{"name":"School of Medicine University of California San Francisco (UCSF)  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.A.","family":"Reid","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Rutishauser","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Cope","sequence":"additional","affiliation":[{"name":"Waterborne Disease Prevention Branch Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jevon","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Washington Hospital Healthcare System  Fremont CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana M.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Infectious Diseases Pathology Branch CDC  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almea","family":"Matanock","sequence":"additional","affiliation":[{"name":"Epidemic Intelligence Service CDC  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibne","family":"Ali","sequence":"additional","affiliation":[{"name":"Waterborne Disease Prevention Branch Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Doernberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Hilts\u2010Horeczko","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"DeMarco","sequence":"additional","affiliation":[{"name":"Department of Cardiology UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiology UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-4959","authenticated-orcid":false,"given":"Jennifer M.","family":"Babik","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases UCSF  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1165","article-title":"Balamuthia mandrillaris transmitted through organ transplantation\u2014Mississippi, 2009","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"MMWR Morbid Mortal Wkly Rep"},{"key":"e_1_2_8_3_1","first-page":"1182","article-title":"Notes from the field: Transplant\u2010transmitted Balamuthia mandrillaris\u2014Arizona, 2010","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"MMWR Morbid Mortal Wkly Report"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12131"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2012.03.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/archderm.1995.01690230069011","article-title":"Disseminated acanthamoebiasis in patients with AIDS","volume":"131","author":"Murakawa G","year":"1995","journal-title":"Arch Dermatol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/000976-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/341973"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1305.061347"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407143310204"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199901000-00010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2005.00113.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00159.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00535.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.132239"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv104"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000061"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198209000-00007"},{"key":"e_1_2_8_19_1","first-page":"1237","article-title":"Cutaneous acanthamoebiasis in a lung transplant patient","volume":"128","author":"Van Hamme C","year":"2001","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.09.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02850.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00649-06"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01168.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00254.x"},{"key":"e_1_2_8_25_1","first-page":"346","article-title":"Disseminated Acanthamoeba infection in a renal transplant recipient: A case report","volume":"50","author":"Mutreja D","year":"2007","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21409"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883846"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis626"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2004.01.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.695-701.2002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2005.00082.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.070854"},{"key":"e_1_2_8_33_1","first-page":"666","article-title":"Investigational drug available directly from CDC for the treatment of infections with free\u2010living amebae","volume":"62","author":"Centers for Disease Control and Prevention","year":"2013","journal-title":"MMWR Morbid Mortal Wkly Rep"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:03:19Z","timestamp":1695474199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,6]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/tid.12661"],"URL":"https:\/\/doi.org\/10.1111\/tid.12661","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,6]]},"article-number":"e12661"}}