{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:17:00Z","timestamp":1776734220216,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Latent tuberculosis (TB<\/jats:styled-content>) infection (LTBI<\/jats:styled-content>) is screened by using clinical assessment, tuberculin skin test (TST<\/jats:styled-content>), chest radiography, and recently by interferon\u2010gamma release assays (IGRA<\/jats:styled-content>). The objective of this study was to evaluate the diagnostic potential of QuantiFERON<\/jats:styled-content>\u00ae<\/jats:sup>\u2010TB<\/jats:styled-content> Gold In\u2010Tube test (QFT<\/jats:styled-content>) for diagnosing LTBI<\/jats:styled-content> in patients planned for kidney transplantation.<\/jats:p><\/jats:sec>Methods<\/jats:title>All adult patients with end\u2010stage renal disease, evaluated for kidney transplantation in a referral center from August 2008 till May 2013, were enrolled, after consenting in a prospective, observational, non\u2010interventional study. LTBI<\/jats:styled-content> diagnosis was conducted by TST<\/jats:styled-content>, chest x\u2010ray, and clinical assessment, followed by IGRA<\/jats:styled-content> by QFT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 278 patients were enrolled and kidney transplantation was performed in 173 patients. Contributed follow\u2010up was 836.5 patient\u2010years, and TB<\/jats:styled-content>\u2010free transplant duration was 478.5 patient\u2010years. By standard methods, LTBI<\/jats:styled-content> was diagnosed in 14 patients. Peri\u2010transplant chemoprophylaxis was given to 53 patients, which included recipients of organs from all deceased donors and living donors with LTBI<\/jats:styled-content>. QFT<\/jats:styled-content> was positive in 70 patients, negative in 200 patients, and indeterminate in 8 patients. The agreement between LTBI<\/jats:styled-content> diagnosis using standard methods and IGRA<\/jats:styled-content> by QFT<\/jats:styled-content> was poor (kappa: 0.089+0.046, P<\/jats:italic>\u2010value=.017). Twenty\u2010seven of the QFT<\/jats:styled-content>\u2010positive patients were transplanted and only one was given isoniazid preventive therapy. None of the transplant recipients developed TB<\/jats:styled-content> after a median follow\u2010up of 25\u00a0months (range 2\u201058\u00a0months, mean 27\u00a0months).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The agreement of the QFT<\/jats:styled-content> with standard diagnosis of LTBI<\/jats:styled-content> in kidney transplant recipients was poor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12675","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T14:52:48Z","timestamp":1486479168000},"source":"Crossref","is-referenced-by-count":23,"title":["Diagnostic potential of interferon\u2010gamma release assay to detect latent tuberculosis infection in kidney transplant recipients"],"prefix":"10.1111","volume":"19","author":[{"given":"Jameela","family":"Edathodu","sequence":"first","affiliation":[{"name":"Department of Medicine King Faisal Specialist Hospital and Research Centre (KFSHRC) Riyadh Saudi 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Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahal","family":"Al\u2010Hajoj","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunity KFSHRC Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Global Tuberculosis Report 2013","author":"World Health Organization","year":"2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2767"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903023200901"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/77.1.1039"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000169068"},{"key":"e_1_2_7_7_1","first-page":"6","article-title":"Tuberculosis in hemodialysis patients","volume":"7","author":"Hussein M","year":"1996","journal-title":"Saudi J Kidney Dis 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