{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:19:42Z","timestamp":1792253982944,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) is a complication of allogeneic stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>), associated with factors such as <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> polyomavirus reactivation, age, conditioning regimen, and presence of graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>). The incidence and impact of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> in patients receiving fludarabine (Flu), busulfan (Bu), and anti\u2010thymocyte globulin (<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) conditioning is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2010control study of patients undergoing <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> at our center between January 1, 2003 and Dec 31, 2012, to determine the incidence of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> and its effect on patient outcomes including overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>), relapse, non\u2010relapse mortality (NRM), <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>, and healthcare resource use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 94 cases of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> were identified and matched to controls based on age, donor type, disease type, and disease status at transplantation. The total incidence of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> was 17.7% (117 of 661 patients). Cases had a higher rate (43.6% vs 27.1%, <jats:italic>P<\/jats:italic>=.0394) of acute <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> (Grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>), and chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> requiring systemic steroids (34.9% vs 18.6%, <jats:italic>P<\/jats:italic>=.004). Male gender was found to be a risk factor (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>]=1.725, <jats:italic>P<\/jats:italic>=.017). <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and progression\u2010free survival did not differ between cases and controls (<jats:styled-content style=\"fixed-case\">OS HR<\/jats:styled-content>=1.128, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.7807\u20101.639; progression\u2010free survival <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=0.8809, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.6320\u20101.234), however the rate of NRM was higher in cases (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=1.632, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.007\u20102.830). Median length of hospitalization was longer for patients with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> than matched controls (65.5\u00a0days vs 40.5\u00a0days, <jats:italic>P<\/jats:italic>&lt;.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> is common in patients undergoing allogeneic <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> with FluBu<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> conditioning, and affects the duration of hospitalization. Rate of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> is higher among patients with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. While <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> is not affected, an association was seen with higher NRM in our study. Improvement in treatment for <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> may lead to reductions in morbidity and healthcare resource utilization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12677","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T21:52:44Z","timestamp":1487195564000},"source":"Crossref","is-referenced-by-count":14,"title":["Incidence and risk factor of hemorrhagic cystitis after allogeneic transplantation with fludarabine, busulfan, and anti\u2010thymocyte globulin myeloablative conditioning"],"prefix":"10.1111","volume":"19","author":[{"given":"Wilson","family":"Lam","sequence":"first","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Storek","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Community Health Sciences University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Geddes","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Daly","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies University of Calgary  Calgary AB 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