{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:17:54Z","timestamp":1790252274511,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Human herpesvirus 6 (\n HHV<\/jats:styled-content>\n \u20106) encephalitis\/myelitis is now a well\u2010known complication after allogeneic stem cell transplantation (allo\u2010\n HSCT<\/jats:styled-content>\n ), particularly after cord blood transplantation (\n CBT<\/jats:styled-content>\n ). In this study, we evaluated the risk factors of\n HHV<\/jats:styled-content>\n \u20106 encephalitis\/myelitis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We evaluated 253 patients who received allo\u2010\n HSCT<\/jats:styled-content>\n from 2007 to 2015 at our institute.\n HHV<\/jats:styled-content>\n \u20106 encephalitis\/myelitis was defined as\n HHV<\/jats:styled-content>\n \u20106\n DNA<\/jats:styled-content>\n detection in the cerebrospinal fluid or peripheral blood by polymerase chain reaction in the presence of typical manifestations without other concurrent condition that led to the manifestations.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HHV<\/jats:styled-content>\n \u20106 encephalitis\/myelitis occurred in 11 patients (4.5%) (9 encephalitis, 3.7%; 2 myelitis, 0.8%). Multivariate analysis showed that\n CBT<\/jats:styled-content>\n , mycophenolate mofetil (\n MMF<\/jats:styled-content>\n ) for graft\u2010versus\u2010host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo\u2010\n HSCT<\/jats:styled-content>\n ), and engraftment syndrome (\n ES<\/jats:styled-content>\n ) were significantly associated with incidence of\n HHV<\/jats:styled-content>\n \u20106 encephalitis\/myelitis (\n P<\/jats:italic>\n =.025,\n P<\/jats:italic>\n =.017,\n P<\/jats:italic>\n =.017, and\n P<\/jats:italic>\n =.014, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Although it has been shown that\n CBT<\/jats:styled-content>\n ,\n ES<\/jats:styled-content>\n , and history of allo\u2010\n HSCT<\/jats:styled-content>\n are risk factors for\n HHV<\/jats:styled-content>\n \u20106 encephalitis\/myelitis, our study demonstrated\n MMF<\/jats:styled-content>\n is also a risk factor for the disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12682","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T16:52:39Z","timestamp":1487263959000},"source":"Crossref","is-referenced-by-count":39,"title":["Risk factors of human herpesvirus 6 encephalitis\/myelitis after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Naohiro","family":"Miyashita","sequence":"first","affiliation":[{"name":"Department of Hematology Hokkaido University Graduate School of Medicine Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Hematology Hokkaido University Graduate School of Medicine Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Onozawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Hokkaido University Graduate School of Medicine 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