{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:47:07Z","timestamp":1753879627301,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although chronic hepatitis C is still the leading indication for liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) in the United States and Europe, acute liver failure caused by hepatitis C is distinctly uncommon and transplantation for fulminant hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) has not been documented in the United States. We present a case report of fulminant hepatic failure caused by genotype 2a\/c <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> not only treated with <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> but also complicated by severe, rapid recurrence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> within 6\u00a0days of transplantation. The risk factor for the initial infection was likely sexual, and there were no explanations for acute hepatitis post\u2010transplant other than recurrent hepatitis C. Treatment with all\u2010oral direct antiviral agents was swiftly initiated during the index hospitalization, leading to resolution of the acute hepatitis and resulting in sustained virologic response. It can only be speculated whether this was an infection with the <jats:styled-content style=\"fixed-case\">JFH<\/jats:styled-content>\u20101 strain or another similarly virulent genotype 2a\/c <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/tid.12690","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T18:46:41Z","timestamp":1488998801000},"source":"Crossref","is-referenced-by-count":5,"title":["Liver transplantation for fulminant genotype 2a\/c hepatitis C\u00a0virus marked by a rapid recurrence followed by cure"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-3608","authenticated-orcid":false,"given":"Brett","family":"Tracy","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial University Medical Center  Savannah GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Transplantation Piedmont Transplant Institute  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Transplantation Piedmont Transplant Institute  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devina","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Department of Transplantation Piedmont Transplant Institute  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison","family":"Pollinger","sequence":"additional","affiliation":[{"name":"Department of Transplantation Piedmont Transplant Institute  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond A.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Transplantation Piedmont Transplant Institute  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"volume-title":"OPTN\/SRTR 2012 Annual Data Report","year":"2014","author":"Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR)","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2013.03.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.t01-1-07223.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608293350904"},{"key":"e_1_2_6_7_1","first-page":"282","volume-title":"Progress in Liver Diseases","author":"Trey C","year":"1970"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000064365.54197.9E"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20273"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.023"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-014-0454-x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01008-09"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1055"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130122"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00781.x"},{"key":"e_1_2_6_16_1","first-page":"396","article-title":"Fibrosing cholestatic hepatitis: Clinicopathologic spectrum, diagnosis and pathogenesis","volume":"1","author":"Xiao SY","year":"2008","journal-title":"Int J Clin Pathol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28446"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512612"},{"key":"e_1_2_6_20_1","unstructured":"Centers for Disease Control and Prevention.Hepatitis C FAQs for Health Care Professionals;2016. 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