{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:58:53Z","timestamp":1790837933914,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most epidemiologic studies of opportunistic infections (<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>) following abdominal organ transplantation are derived prior to the era of contemporary immunosuppression and prophylaxis. These studies suggest that most <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> occur within the first 6\u00a0months post transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this single\u2010center, retrospective cohort study, we describe the epidemiology of <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> in 359 consecutive abdominal organ transplant recipients, in the era of contemporary prophylaxis practices and alemtuzumab induction in kidney and simultaneous pancreas\u2010kidney transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety patients (25.1%) developed <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>, with 53.3% of these occurring beyond 6\u00a0months. The most common <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> were <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> polyomavirus nephropathy (5.0%), cytomegalovirus (10.2%), varicella zoster virus (4.4%), and herpes simplex virus (1.1%), which typically occurred after discontinuation of antiviral prophylaxis, and <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>lostridium difficile<\/jats:italic> infections (7.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> had no impact on patient or graft survival at 12\u00a0months post transplant. In the era of contemporary immunosuppression and prophylaxis, a significant proportion of <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> occur beyond 6\u00a0months. Additional strategies may be important to reduce the incidence of such late\u2010onset infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12691","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T18:52:55Z","timestamp":1488999175000},"source":"Crossref","is-referenced-by-count":19,"title":["A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Mia","family":"Helfrich","sequence":"first","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dorschner","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative  Chicago IL 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