{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:00:37Z","timestamp":1778925637257,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>No data are available on clinical manifestations and course of norovirus gastroenteritis (NVE<\/jats:styled-content>) in intestinal allograft (from intestinal and multivisceral transplant recipients, ITR<\/jats:styled-content>) compared to native intestine (from other allograft recipients, nITR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective study of solid organ transplant recipients with NVE<\/jats:styled-content> at two centers from January 1, 2010 to April 1, 2014. Chi\u2010square, t\u2010test, linear and logistic regression analyses were done to compare NVE<\/jats:styled-content> in ITR<\/jats:styled-content> vs nITR<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Results<\/jats:title>The ITR<\/jats:styled-content> (45 patients) were compared to nITR<\/jats:styled-content> (107 patients). ITR<\/jats:styled-content> were younger (odds ratio [OR<\/jats:styled-content>]=0.90; P<\/jats:italic><.0001), less likely to receive anti\u2010lymphocyte induction therapy (OR<\/jats:styled-content>=0.15; P<\/jats:italic><.0001), and had shorter time from transplant to NVE<\/jats:styled-content> (OR<\/jats:styled-content>=0.99; P<\/jats:italic>=.008). On presentation ITR<\/jats:styled-content> had less frequent nausea (OR<\/jats:styled-content>=0.11; P<\/jats:italic><.0001) or vomiting (OR<\/jats:styled-content>=0.36; P<\/jats:italic>=.01), higher white blood cell count (OR<\/jats:styled-content>=1.09; P<\/jats:italic>=.001), and higher glomerular filtration rate (OR<\/jats:styled-content>=1.02; P<\/jats:italic><.0001). ITR<\/jats:styled-content> were less likely to receive anti\u2010motility agents (OR<\/jats:styled-content>=9.6; P<\/jats:italic><.0001). ITR<\/jats:styled-content> were more likely to stay longer on intravenous (IV<\/jats:styled-content>) fluids (OR<\/jats:styled-content>=1.18; P<\/jats:italic><.0001); have recurrent NVE<\/jats:styled-content> (OR<\/jats:styled-content>=4.25; P<\/jats:italic><.0001); have longer hospital stay (OR<\/jats:styled-content>=1.07; P<\/jats:italic><.0001); develop acute rejection (OR<\/jats:styled-content>=5.1; P<\/jats:italic>=.006); and have lower overall survival (OR<\/jats:styled-content>=0.28; P<\/jats:italic>=.006).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared to nITR<\/jats:styled-content>, the ITR<\/jats:styled-content> with NVE<\/jats:styled-content> were significantly younger, had less nausea and vomiting at presentation, received less anti\u2010motility agents, required more IV<\/jats:styled-content> fluids, and had longer hospital stay. A trend was seen for lower survival with NVE<\/jats:styled-content> in ITR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12692","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T18:52:49Z","timestamp":1488999169000},"source":"Crossref","is-referenced-by-count":4,"title":["Clinical presentation and outcomes of norovirus infection in intestinal allograft compared to native intestine"],"prefix":"10.1111","volume":"19","author":[{"given":"Diana F.","family":"Florescu","sequence":"first","affiliation":[{"name":"Transplant Infectious Diseases Program University of Nebraska Medical Center Omaha NE USA"},{"name":"Transplant Surgery Program University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L.","family":"Sonderup","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Grant","sequence":"additional","affiliation":[{"name":"Transplant Surgery Program University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pearlie P.","family":"Chong","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-3227","authenticated-orcid":false,"given":"David","family":"van Duin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre C.","family":"Kalil","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Program University of Nebraska Medical Center Omaha NE 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