{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:14:50Z","timestamp":1789017290150,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory virus infection (<jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content>) is a prevalent infection in patients after allogeneic hematopoietic stem cell transplant (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) and can result in significant morbidity and mortality. Ability to assess the potential severity of <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content> is important in the management of such patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the cases of <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content> in allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients and explored the predictive value of the immunodeficiency scoring index (<jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content>) established for respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>) and its applicability for <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content> caused by other respiratory viruses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RVI occurred year\u2010round in our tropical transplant center, with peaks in the middle and end of the year. Ninety\u2010five of the 195 recipients developed a total of 191 episodes of <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content>, giving a cumulative incidence of 28% by 6\u00a0months and 52% by 24\u00a0months for the first episode of <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>, influenza, rhinovirus, and parainfluenza were the most common viruses. Pneumonia occurred in 63.64%, 42.31%, and 32.42% of adenovirus, influenza, and <jats:styled-content style=\"fixed-case\">RSV RVI<\/jats:styled-content> episodes, respectively, but was also non\u2010negligible in the more benign viruses, such as coronavirus (31.58%) and rhinovirus (23.68%). Nineteen of the 63 episodes of viral pneumonia required mechanical ventilation and 14 deaths occurred within 6\u00a0weeks of the <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content>. Receiver operating characteristic analysis showed that an <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content> of \u22658 predicted pneumonia with a positive predictive value of &gt;80% for <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content> caused by <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>, influenza, adenovirus, and parainfluenza, while it was not predictive for coronavirus and rhinovirus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content> is a useful aid for decision\u2010making during clinic consultation for patients presenting with symptoms suggestive of an <jats:styled-content style=\"fixed-case\">RVI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12693","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:41:01Z","timestamp":1489167661000},"source":"Crossref","is-referenced-by-count":26,"title":["Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: Predictive value of the immunodeficiency scoring index"],"prefix":"10.1111","volume":"19","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Haematology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Allen","sequence":"additional","affiliation":[{"name":"Academic Medicine Research Institute Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Diong","sequence":"additional","affiliation":[{"name":"Haematology Singapore General Hospital  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