{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:30:09Z","timestamp":1789432209602,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lternaria<\/jats:italic> species have been reported as a rare cause of fungal infection in organ and stem cell transplant recipients, but to date, no reports have been published of infection in humans caused by <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lternaria rosae<\/jats:italic>. Here, we report cutaneous <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0rosae<\/jats:italic> infection in a 66\u2010year\u2010old farmer with a history of primary myelofibrosis who had undergone allogeneic unrelated donor hematopoietic stem cell transplantation. Forty\u2010nine days post transplant, he presented with a nodule on the thumb with no findings suggestive of disseminated infection. Pathology, culture, and molecular speciation showed the nodule was caused by cutaneous <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0rosae<\/jats:italic>. He had been on voriconazole as antifungal prophylaxis, but was found to have a subtherapeutic voriconazole level. He was switched to posaconazole based on published in vitro data showing its superior efficacy in <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lternaria<\/jats:italic> treatment. Susceptibility testing showed that the <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic>.\u00a0<jats:italic>rosae<\/jats:italic> isolate was indeed susceptible to posaconazole. His cutaneous lesion remained stable, but he died from respiratory failure secondary to lobar pneumonia. At lung autopsy, <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0rosae<\/jats:italic> was not identified in the lungs. We believe this to be the first published report, to our knowledge, of <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0rosae<\/jats:italic> infection in humans.<\/jats:p>","DOI":"10.1111\/tid.12698","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T18:07:43Z","timestamp":1489514863000},"source":"Crossref","is-referenced-by-count":8,"title":["Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by <i>Alternaria rosae<\/i>: First case report"],"prefix":"10.1111","volume":"19","author":[{"given":"Amy W.","family":"Liu","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Washington  Seattle WA USA"},{"name":"Division of Medical Oncology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanishka","family":"Garvin","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Clarridge","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle WA USA"},{"name":"Pathology and Laboratory Medicine Service Veterans Affairs Puget Sound Health Care System  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Grim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology University of Washington  Seattle WA USA"},{"name":"Hospital and Specialty Medicine, Medical Oncology Section Veterans Affairs Puget Sound Health Care System  Seattle WA USA"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle WA 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