{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:16:31Z","timestamp":1783444591205,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serological diagnosis of flavivirus infection is a challenge, particularly in the context of a disease associated with immune response enhancement in a transplant patient, where aspects such as previous flavivirus infections may be involved with the outcome. We report a case of a pediatric patient who developed Guillain\u2010Barr\u00e9 syndrome (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) after matched\u2010unrelated hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). The patient lives in a Brazilian region that is experiencing an epidemic of Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>) and dengue virus (<jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>). Because an increasing number of cases of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, likely triggered by <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection, are being reported in Brazil, samples from the patient were tested for both <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content> infection. Serological assays strongly suggested a recent <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection, although infection by <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content> or co\u2010infection with both viruses cannot be ruled out. The presence of anti\u2010<jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content> immunoglobulin\u2010G in donor serum led to the hypothesis that antibodies from the donor could have enhanced the severity of the <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection. This hypothesis is in agreement with the recent findings that <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content> sero\u2010cross\u2010reactivity drives antibody\u2010dependent enhancement of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection. These findings highlight the need for discussion of the indication to perform previous flavivirus tests in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> donors, especially in areas where <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> and other flaviviruses co\u2010circulate.<\/jats:p>","DOI":"10.1111\/tid.12700","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T15:15:06Z","timestamp":1489763706000},"source":"Crossref","is-referenced-by-count":9,"title":["Flavivirus cross\u2010reactivity in serological tests and Guillain\u2010Barr\u00e9 syndrome in a hematopoietic stem cell transplant patient: A case report"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-7585","authenticated-orcid":false,"given":"Sonia M.","family":"Raboni","sequence":"first","affiliation":[{"name":"Laboratory of Virology Universidade Federal do Paran\u00e1  Paran\u00e1 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