{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:49Z","timestamp":1790267089480,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Legionnaires' disease (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>) can be fatal among high\u2010risk transplant recipients. To understand the epidemiology of<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>, we reviewed 15\u2010year longitudinal data from a center in Seattle, Washington that cares for both solid organ transplant (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) and hematopoietic cell transplant (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) recipients. We identified all laboratory\u2010confirmed<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>and extracted data on species, diagnostic modalities, clinical presentation, management, and outcomes from medical records. Among 32 patients with<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>, transplant recipients made up the majority of diagnoses (22, 69%;<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>10,<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>12). Approximately 0.8% of transplant recipients who underwent<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>egionella\u2010<\/jats:italic>specific testing were positive. Non\u2010<jats:italic>pneumophila<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>egionella<\/jats:italic>species (<jats:styled-content style=\"fixed-case\">LNLP<\/jats:styled-content>), which are not detected by urinary antigen test, accounted for half the cases, led by<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>egionella micdadei<\/jats:italic>(32%). The severity and outcome between<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>egionella pneumophila<\/jats:italic>and<jats:styled-content style=\"fixed-case\">LNLP<\/jats:styled-content>infections were similar (attributed mortality, 36% vs 27%); all<jats:styled-content style=\"fixed-case\">LNLP<\/jats:styled-content>deaths occurred in transplant recipients with<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.\u00a0micdadei<\/jats:italic>. The clinical and radiological features mimicked other opportunistic pathogens; 32% (n=7) were not on empiric treatment at the time of diagnosis. These data add to the emerging literature describing the importance of<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>and highlight the need for both routine<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>egionella<\/jats:italic>testing on transplant recipients with pulmonary findings and empiric<jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>egionella<\/jats:italic>\u2010active antibiotic therapy.<\/jats:p>","DOI":"10.1111\/tid.12745","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T09:29:37Z","timestamp":1499765377000},"source":"Crossref","is-referenced-by-count":35,"title":["Legionnaires' disease in transplant recipients: A 15\u2010year retrospective study in a tertiary referral center"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-7087","authenticated-orcid":false,"given":"Shobini","family":"Sivagnanam","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Podczervinski","sequence":"additional","affiliation":[{"name":"Infection Prevention Seattle Cancer Care Alliance Seattle WA USA"},{"name":"Washington State Department of Health Shoreline WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Butler\u2010Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Washington State Department of Health Shoreline WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zach","family":"Stednick","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois A.","family":"Helbert","sequence":"additional","affiliation":[{"name":"Infection Prevention Seattle Cancer Care Alliance Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Glover","sequence":"additional","affiliation":[{"name":"Washington State Department of Health Shoreline WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella","family":"Whimbey","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Duchin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA USA"},{"name":"Public Health \u2013 Seattle and King County Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Shing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA USA"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Pergam","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Infection Prevention Seattle Cancer Care Alliance Seattle WA USA"},{"name":"Department of Medicine University of Washington Seattle WA USA"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110923"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328364f573"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2010.11.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/342884"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2010.090134"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1128\/jcm.20.4.605-607.1984","article-title":"Onset and duration of urinary antigen excretion in Legionnaires disease","volume":"20","author":"Kohler RB","year":"1984","journal-title":"J Clin Microbiol"},{"key":"e_1_2_10_8_1","unstructured":"United States Census Bureau [Internet].https:\/\/www.census.gov\/quickfacts\/. 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