{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:01:42Z","timestamp":1790517702253,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:00:00Z","timestamp":1505520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n BK<\/jats:styled-content>\n polyomavirus (\n BKP<\/jats:styled-content>\n yV) reactivation is a common clinical occurrence in kidney transplant recipients (\n KTR<\/jats:styled-content>\n ). Several other polyomaviruses have been implicated as pathogens with a direct role in the development of malignancies, raising the question of whether\n BKP<\/jats:styled-content>\n yV might also be oncogenic.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study is the first retrospective, multicenter cohort study evaluating the relative risk for urothelial cell carcinoma (\n UCC<\/jats:styled-content>\n ) associated with\n BKP<\/jats:styled-content>\n yV infection among\n KTR<\/jats:styled-content>\n , and was conducted among veterans who underwent transplantation between 2000 and 2009.\n BKP<\/jats:styled-content>\n yV cases were defined as those veterans with any clinical evidence of\n BKP<\/jats:styled-content>\n yV infection, including positive polymerase chain reaction testing of urine and\/or serum for\n BKP<\/jats:styled-content>\n yV or kidney biopsy showing\n BKP<\/jats:styled-content>\n yV\u2010associated nephropathy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among the 646 veterans who met inclusion criteria for the study, 103 had clinical evidence of\n BKP<\/jats:styled-content>\n yV infection (16%). The overall relative risk for developing any malignancy after\n BKP<\/jats:styled-content>\n yV infection was 1.13 (95% confidence interval [\n CI<\/jats:styled-content>\n ] 0.89\u20101.44). The adjusted relative risk for malignancy after\n BKP<\/jats:styled-content>\n yV infection was greatest with\n UCC<\/jats:styled-content>\n (8.21, 95%\n CI<\/jats:styled-content>\n 0.75\u201089.7) and with metastatic disease of unknown etiology (8.21, 95%\n CI<\/jats:styled-content>\n 0.75\u201089.7). The screening prevalence for\n BKP<\/jats:styled-content>\n yV infection increased from 18% for those veterans who underwent transplantation in 2000 to 86% for those veterans who underwent transplantation in 2009, during which time the measured prevalence of\n BKP<\/jats:styled-content>\n yV infection increased from 7% to 24%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this cohort of\n KTR<\/jats:styled-content>\n veterans, no overall increased or decreased relative risk for malignancy was associated with evidence of prior\n BKP<\/jats:styled-content>\n yV infection. A >8\u2010fold increased risk of developing\n UCC<\/jats:styled-content>\n after\n BKP<\/jats:styled-content>\n yV infection was seen, although this risk was not found to be statistically significant.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12752","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T11:16:50Z","timestamp":1500549410000},"source":"Crossref","is-referenced-by-count":23,"title":["Urothelial cell carcinoma after BK polyomavirus infection in kidney transplant recipients: A cohort study of veterans"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-0188","authenticated-orcid":false,"given":"Ralph","family":"Rogers","sequence":"first","affiliation":[{"name":"Department of Medicine Providence VA Medical Center Providence RI USA"},{"name":"Department of Medicine Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginald","family":"Gohh","sequence":"additional","affiliation":[{"name":"Department of Medicine Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Noska","sequence":"additional","affiliation":[{"name":"Department of Medicine Providence VA Medical Center Providence RI USA"},{"name":"Department of Medicine Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001333"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.12.015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12110"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12728"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91776-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130227"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.10.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13550"},{"key":"e_1_2_6_10_1","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 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