{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:31Z","timestamp":1787016031855,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Urinary tract infections (\n UTI<\/jats:styled-content>\n s) are the most common infectious complications among renal transplant recipients (\n RTR<\/jats:styled-content>\n ).\n UTI<\/jats:styled-content>\n s caused by extended\u2010spectrum beta\u2010lactamase (\n ESBL<\/jats:styled-content>\n )\u2010producing Enterobacteriaceae (\n ESBL<\/jats:styled-content>\n \u2010\n PE<\/jats:styled-content>\n ) have been associated with inferior clinical outcomes and increased financial burden.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed a systematic review and meta\u2010analysis by searching through the PubMed and\n EMBASE<\/jats:styled-content>\n databases (to May 20, 2016) and identifying studies that reported data on the number of\n RTR<\/jats:styled-content>\n who developed an\n ESBL<\/jats:styled-content>\n \u2010\n PE UTI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Our analysis included seven studies, out of 357 non\u2010duplicate articles, that provided data on 2824 patients. Among them, 10% (95% confidence interval [\n CI<\/jats:styled-content>\n ] 4%\u201017%) developed an\n ESBL<\/jats:styled-content>\n \u2010\n PE UTI<\/jats:styled-content>\n over their follow\u2010up periods. The proportion of\n RTR<\/jats:styled-content>\n affected by an\n ESBL<\/jats:styled-content>\n \u2010\n PE UTI<\/jats:styled-content>\n was 2% in North America (95%\n CI<\/jats:styled-content>\n 1%\u20103%), 5% in Europe (95%\n CI<\/jats:styled-content>\n 4%\u20106%), 17% in South America (95%\n CI<\/jats:styled-content>\n 10%\u201027%), and 33% in Asia (95%\n CI<\/jats:styled-content>\n 27%\u201041%). In addition, patients affected with an\n ESBL<\/jats:styled-content>\n \u2010\n PE UTI<\/jats:styled-content>\n were 2.75\u2010times (95%\n CI<\/jats:styled-content>\n 1.97\u20103.83) more likely to suffer a recurrent\n UTI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Based on a limited number of studies, one in 10\n RTR<\/jats:styled-content>\n will develop a\n UTI<\/jats:styled-content>\n caused by an\n ESBL<\/jats:styled-content>\n \u2010\n PE<\/jats:styled-content>\n , and these patients face an almost 3 times greater risk of recurrence. A more rigorous monitoring of\n RTR<\/jats:styled-content>\n , both during and after resolution of their infection, should be evaluated in order to reduce the incidence and the clinical impact of these resistant infections.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12759","type":"journal-article","created":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T01:26:35Z","timestamp":1502587595000},"source":"Crossref","is-referenced-by-count":54,"title":["Urinary tract infections caused by\n ESBL<\/scp>\n \u2010producing Enterobacteriaceae in renal transplant recipients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Michail","family":"Alevizakos","sequence":"first","affiliation":[{"name":"Infectious Diseases Division Warren Alpert Medical School of Brown University Rhode Island Hospital Rhode Island RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Nasioudis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-0777","authenticated-orcid":false,"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Warren Alpert Medical School of Brown University Rhode Island Hospital Rhode Island RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883901"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00519.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182a04997"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01700.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.236.175"},{"key":"e_1_2_9_7_1","first-page":"1311","article-title":"Urinary tract infections following renal transplantation: A single\u2010center experience","volume":"23","author":"Barbouch S","year":"2012","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.05.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.02.060"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.05.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/319757"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/1040841X.2013.875515","article-title":"Colonization and infection with extended spectrum beta\u2010lactamase producing Enterobacteriaceae in high\u2010risk patients \u2013 Review of the literature from a clinical perspective","volume":"42","author":"Biehl LM","year":"2016","journal-title":"Crit Rev Microbiol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks301"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/cid\/civ003","article-title":"Carbapenem therapy is associated with improved survival compared with piperacillin\u2010tazobactam for patients with extended\u2010spectrum beta\u2010lactamase bacteremia","volume":"60","author":"Tamma PD","year":"2015","journal-title":"Clin Infect Dis"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2157"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12366"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.02014.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12124"},{"key":"e_1_2_9_20_1","unstructured":"WellsGA SheaB O'ConnellD et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses.2000.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. 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