{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:22:50Z","timestamp":1780428170151,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Kidney transplant recipients who are switched to atovaquone (ATO<\/jats:styled-content>) from trimethoprim\u2010sulfamethoxazole (TMP<\/jats:styled-content>\/SMX<\/jats:styled-content>) for Pneumocystis jirovecii<\/jats:italic> pneumonia (PJP<\/jats:styled-content>) prophylaxis because of adverse events or complications may miss opportunities to be re\u2010challenged with TMP<\/jats:styled-content>\/SMX<\/jats:styled-content>, the first\u2010line agent. This single\u2010site, retrospective study assessed kidney transplant recipients for documented reasons for switching from TMP<\/jats:styled-content>\/SMX<\/jats:styled-content> to alternate PJP<\/jats:styled-content> prophylaxis and outcomes of TMP<\/jats:styled-content>\/SMX<\/jats:styled-content> re\u2010challenge. Out of 166 patients, 155 initially received TMP<\/jats:styled-content>\/SMX<\/jats:styled-content>; of these, 31 were switched to ATO<\/jats:styled-content> for various reasons. Fourteen patients receiving ATO<\/jats:styled-content> were re\u2010challenged with TMP<\/jats:styled-content>\/SMX<\/jats:styled-content>; all were successfully re\u2010initiated on TMP<\/jats:styled-content>\/SMX<\/jats:styled-content> therapy. Most patients switched to ATO<\/jats:styled-content> post kidney transplant secondary to non\u2010hypersensitivity reasons should be re\u2010challenged with TMP<\/jats:styled-content>\/SMX<\/jats:styled-content> because of the advantages it provides over other agents.<\/jats:p>","DOI":"10.1111\/tid.12769","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T09:12:41Z","timestamp":1503306761000},"source":"Crossref","is-referenced-by-count":12,"title":["Switch to atovaquone and subsequent re\u2010challenge with trimethoprim\u2010sulfamethoxazole for Pneumocystis<\/i> prophylaxis in a kidney transplant population"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-185X","authenticated-orcid":false,"given":"Milena M.","family":"McLaughlin","sequence":"first","affiliation":[{"name":"Pharmacy Practice Midwestern University Chicago College of Pharmacy Downers Grove IL USA"},{"name":"Department of Pharmacy Northwestern 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