{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:49:09Z","timestamp":1773985749906,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>With the advent of effective antivirals against cytomegalovirus (CMV<\/jats:styled-content>), use of CMV<\/jats:styled-content> hyperimmune globulin (HIG) has decreased. Although antiviral prophylaxis in patients at high risk for CMV<\/jats:styled-content> is effective, many patients still have late infection, never developing antibodies sufficient to achieve immunity. Utilizing a combination of antiviral and CMV<\/jats:styled-content> HIG may allow patients to achieve immunity and decrease late CMV<\/jats:styled-content> infections.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a prospective randomized, open\u2010label, pilot study comparing valganciclovir (VGCV<\/jats:styled-content>) prophylaxis for 200\u00a0days vs VGCV<\/jats:styled-content> for 100\u00a0days followed by CMV HIG<\/jats:styled-content> in abdominal transplant recipients at high risk for CMV<\/jats:styled-content>. The primary outcome was a comparison of late CMV<\/jats:styled-content> disease.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty patients were randomized to VGCV<\/jats:styled-content> for 200\u00a0days (n\u00a0=\u00a020) or VGCV<\/jats:styled-content> for 100\u00a0days followed by 3 doses of monthly CMV HIG<\/jats:styled-content> (n\u00a0=\u00a020). Numerically, more overall CMV<\/jats:styled-content> infections occurred in the CMV HIG<\/jats:styled-content> group (45 vs 20%, P<\/jats:italic>\u00a0=\u00a0.09). No differences in overall CMV<\/jats:styled-content> infections or late CMV<\/jats:styled-content> disease were seen between groups (20% vs 15%, P<\/jats:italic>\u00a0=\u00a01.00 and 0 vs 0, P<\/jats:italic>\u00a0=\u00a01.00). All CMV<\/jats:styled-content> disease occurred within 200\u00a0days, with 63% occurring while patients were on VGCV<\/jats:styled-content>. No differences were found in toxicities, graft function, or rejection between groups. Patients with CMV<\/jats:styled-content> infection at any time had a higher body weight than those who did not have an infection (82 vs 95\u00a0kg, P<\/jats:italic>\u00a0=\u00a0.049).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Use of CMV HIG<\/jats:styled-content> sequentially with prophylaxis may be an effective and affordable prophylactic regimen in abdominal transplant recipients at high risk for CMV<\/jats:styled-content>, and warrants larger prospective study. Increased monitoring for patients with obesity may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12779","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:10:26Z","timestamp":1505743826000},"source":"Crossref","is-referenced-by-count":6,"title":["Valganciclovir (VGCV<\/scp>) followed by cytomegalovirus (CMV<\/scp>) hyperimmune globulin compared to VGCV<\/scp> for 200\u00a0days in abdominal organ transplant recipients at high risk for CMV<\/scp> infection: A prospective, randomized pilot study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-3107","authenticated-orcid":false,"given":"James N.","family":"Fleming","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-4589","authenticated-orcid":false,"given":"David J.","family":"Taber","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina Charleston SC USA"},{"name":"Department of Pharmacy Ralph H Johnson VAMC Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole A.","family":"Weimert","sequence":"additional","affiliation":[{"name":"Division of Transplant Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Nadig","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"McGillicuddy","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles F.","family":"Bratton","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhakar K.","family":"Baliga","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Chavin","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Transplant Surgery Transplant Institute University Hospitals Cleveland Medical Center Cleveland OH USA"},{"name":"Department of Surgery Case Western Reserve University School of Medicine Cleveland OH 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