{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:12:09Z","timestamp":1780319529499,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/04691\u20100"],"award-info":[{"award-number":["2014\/04691\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Chagas' disease (CD<\/jats:styled-content>) is caused by infection with the protozoan T<\/jats:styled-content>rypanosoma cruzi<\/jats:italic>. The disease can affect the heart and\/or the gastrointestinal (GI<\/jats:styled-content>) tract, but around 70% of infected individuals remain asymptomatic in the chronic form. Organ transplantation from T<\/jats:styled-content>.\u00a0cruzi<\/jats:italic>\u2010infected donors is often avoided because of the risk of disease transmission, previously reported after heart, kidney, or liver transplantation.<\/jats:p><\/jats:sec>Methods<\/jats:title>We investigated by histology, immunohistochemistry, and polymerase chain reaction (PCR<\/jats:styled-content>) the persistence of T<\/jats:styled-content>.\u00a0cruzi<\/jats:italic> in samples of the heart, lung, liver, kidney, pancreas, adrenal gland, esophagus, and GI<\/jats:styled-content> tract of 21 chronic chagasic patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Parasite persistence was detected in 12\/21 (57.1%) heart samples, mainly by PCR<\/jats:styled-content>\u2010based assays. T<\/jats:styled-content>.\u00a0cruzi<\/jats:italic> parasites were detected by histology and immunohistochemistry in smooth muscle cells of the central vein from 1\/21 (4.8%) adrenal gland samples. No samples of the lung, liver, kidney, pancreas, esophagus, or GI<\/jats:styled-content> tract were found to have parasites by histology, immunohistochemistry, or PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We concluded that, aside from the heart, the other solid organs of T<\/jats:styled-content>.\u00a0cruzi<\/jats:italic>\u2010infected donors can be used for transplantation with a lot of caution. Such organs are not safe in the view of previous reports of CD<\/jats:styled-content> transmission, but seem to present a low T<\/jats:styled-content>.\u00a0cruzi<\/jats:italic> load compared to the heart.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12783","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T13:22:44Z","timestamp":1506345764000},"source":"Crossref","is-referenced-by-count":24,"title":["An autopsy\u2010based study of T<\/scp>rypanosoma cruzi<\/i> persistence in organs of chronic chagasic patients and its relevance for transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Luiz A.","family":"Benvenuti","sequence":"first","affiliation":[{"name":"Heart Institute (InCor) do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Rogg\u00e9rio","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta M.","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Nishiya","sequence":"additional","affiliation":[{"name":"Molecular Biology Department Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue\/S\u00e3o Paulo Blood Center S\u00e3o\u00a0Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E.","family":"Levi","sequence":"additional","affiliation":[{"name":"Molecular Biology Department Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue\/S\u00e3o Paulo Blood Center S\u00e3o\u00a0Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"519","article-title":"Chagas disease (American trypanosomiasis) \u2013 factsheet (revised in August 2012)","volume":"87","author":"World Health Organization","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00361-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.348"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90085-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.435"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762011000100014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12340"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000088"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.01.920"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.220"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2005.06.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.59.784"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001277"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1179\/136485908X311740"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005008061"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/232646"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821991000200002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/598634"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03444.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02107.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12633"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12487"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:07:17Z","timestamp":1696043237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,25]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/tid.12783"],"URL":"https:\/\/doi.org\/10.1111\/tid.12783","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,25]]},"article-number":"e12783"}}