{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:36:12Z","timestamp":1782408972538,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["TFU 127880"],"award-info":[{"award-number":["TFU 127880"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Donors with an increased risk of transmitting human immunodeficiency virus (HIV<\/jats:styled-content>), hepatitis B virus (HBV<\/jats:styled-content>), or hepatitis C virus (HCV<\/jats:styled-content>) (increased risk donors [IRD<\/jats:styled-content>s]) are a potential source of organs for transplant. Organs from IRD<\/jats:styled-content>s can be utilized with appropriate recipient consent and post\u2010transplant follow\u2010up. We reviewed the characteristics and utilization of IRD<\/jats:styled-content>s in our Organ Procurement Organization (OPO<\/jats:styled-content>) over a 2\u2010year period.<\/jats:p><\/jats:sec>Methods<\/jats:title>Donor information from April 1, 2013 to March 31, 2015 was obtained through the OPO<\/jats:styled-content> database. Only consented donors were included. Donors were categorized as IRD<\/jats:styled-content>s according to Health Canada\/Canadian Standards Association (CSA<\/jats:styled-content>) criteria.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 494 potential donors were identified, of which 92 (18.6%) were IRD<\/jats:styled-content>s. Of these, at least one organ was transplanted from 76 (82.6%). Risk factors for IRD<\/jats:styled-content>s included injection drug user (IDU<\/jats:styled-content>) (12%), men having sex with men (MSM<\/jats:styled-content>) (7%), commercial sex worker (CSW<\/jats:styled-content>) (4%), and incarceration (24%). Fifty\u2010nine percent (253\/429) of IRD<\/jats:styled-content> organs were utilized. The most frequently used organ was kidney, followed by liver. Median number of organs recovered per IRD<\/jats:styled-content> was 3 (interquartile range: 2\u20105). Nucleic acid testing (NAT<\/jats:styled-content>) was performed in 18.5% (17\/92) of IRD<\/jats:styled-content>s. Reasons for NAT<\/jats:styled-content> were IDU<\/jats:styled-content> (n\u00a0=\u00a02), MSM<\/jats:styled-content> (n\u00a0=\u00a02), CSW<\/jats:styled-content> (n\u00a0=\u00a02), and previous incarceration (n\u00a0=\u00a07). Organ utilization from donors that had NAT<\/jats:styled-content> was similar to donors who did not (94% vs 80%, P<\/jats:italic>\u00a0=\u00a0.29). Follow\u2010up NAT<\/jats:styled-content> was done in <5% of recipients from IRD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our cohort, IRD<\/jats:styled-content>s comprised a significant proportion of donors. Utilization of IRD<\/jats:styled-content> organs occurred at a significant rate regardless of pre\u2010transplant NAT<\/jats:styled-content>. These data suggest that multiple factors contribute to the perception of infectious risk from such organs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12785","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T14:32:34Z","timestamp":1507213954000},"source":"Crossref","is-referenced-by-count":9,"title":["Organ utilization from increased infectious risk donors: An observational study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9230-7285","authenticated-orcid":false,"given":"Arnaud G.","family":"L'Huillier","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Humar","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Program University of Heath Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Payne","sequence":"additional","affiliation":[{"name":"Trillium Gift of Life Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Kumar","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Program University of Heath Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Organ Procurement and Transplantation Network.Transplant by Donor Type.2017. 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