{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:10:51Z","timestamp":1793772651466,"version":"4.6.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>We aimed to evaluate clinical characteristics, risk factors, and disease outcomes for liver transplant recipients (LTR<\/jats:styled-content>) with post\u2010transplant lymphoproliferative disease (PTLD<\/jats:styled-content>) at our center.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective review of data of all pediatric LTR<\/jats:styled-content> (1991\u20102015) was conducted.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall incidence of PTLD<\/jats:styled-content> was 16.4% (18\/110), the majority (13\/18) were early lesions, while 3\/18 were polymorphic\/monomorphic PTLD<\/jats:styled-content>. The risk factors significant on univariate analysis were as follows: mean age (years) at transplant (1.66 vs 4.76, P<\/jats:italic>\u00a0=\u00a0.006); age <2\u00a0years at transplant (odds ratio [OR<\/jats:styled-content>] 3.53 [95% confidence interval [CI<\/jats:styled-content>]: 1.16\u201010.73], P<\/jats:italic>\u00a0=\u00a0.026); cytomegalovirus (CMV<\/jats:styled-content>) primary infection (OR<\/jats:styled-content> 11.39 [95% CI<\/jats:styled-content>: 3.44\u201037.7], P<\/jats:italic>\u00a0<\u00a0.001); recipient CMV<\/jats:styled-content> seronegativity (OR<\/jats:styled-content> 7.50 [95% CI<\/jats:styled-content>: 2.02\u201027.78], P<\/jats:italic>\u00a0=\u00a0.003); presence of CMV<\/jats:styled-content> end\u2010organ disease (OR<\/jats:styled-content> 4.00 [95% CI<\/jats:styled-content>: 1.22\u201013.16], P<\/jats:italic>\u00a0=\u00a0.022); Chinese ethnicity; and higher mean duration of intravenous ganciclovir prophylaxis. In multivariate analysis, CMV<\/jats:styled-content> primary infection (OR<\/jats:styled-content> 5.22 [95% CI<\/jats:styled-content>: 1.25\u201021.87], P<\/jats:italic>\u00a0=\u00a0.024), CMV<\/jats:styled-content> seronegativity (OR<\/jats:styled-content> 5.91 [95% CI<\/jats:styled-content>: 1.13\u201030.90, P<\/jats:italic>\u00a0=\u00a0.035]), and having acute cellular rejections (ACR<\/jats:styled-content>) prior to PTLD<\/jats:styled-content> (OR<\/jats:styled-content> 5.53 [95% CI<\/jats:styled-content>: 1.43\u201021.48, P<\/jats:italic>\u00a0=\u00a0.013]) were significant risk factors for PTLD<\/jats:styled-content>, with the latter two factors having a synergistic effect in increasing PTLD<\/jats:styled-content> risk in a stratified analysis. The final multivariate model in predicting the risk of PTLD<\/jats:styled-content>, utilizing CMV<\/jats:styled-content> primary infection, recipient CMV<\/jats:styled-content> seronegativity, and ACR<\/jats:styled-content> before PTLD<\/jats:styled-content> as predictive variables, was statistically significant (likelihood ratio chi square statistic\u00a0=\u00a025.18, P<\/jats:italic>\u00a0<\u00a0.0001 with df<\/jats:italic>\u00a0=\u00a03).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We report a unique clinicopathologic and risk factor profile in our cohort\u2014early lesion PTLD<\/jats:styled-content> accounts for the majority and the incidence of monomorphic PTLD<\/jats:styled-content> remains low. In addition, we show a synergism between CMV<\/jats:styled-content> naivety and ACR<\/jats:styled-content> on PTLD<\/jats:styled-content> risk, a higher prevalence of gastrointestinal manifestations, and a lack of significant association with Epstein\u2010Barr virus seronegativity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12798","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T07:32:38Z","timestamp":1509003158000},"source":"Crossref","is-referenced-by-count":13,"title":["Risk factors and clinical outcomes of pediatric liver transplant recipients with post\u2010transplant lymphoproliferative disease in a multi\u2010ethnic Asian cohort"],"prefix":"10.1111","volume":"20","author":[{"given":"James Guoxian","family":"Huang","sequence":"first","affiliation":[{"name":"Khoo Teck Puat \u2013 National University Children's Medical Institute National University Health System Singapore"},{"name":"Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervin Ye Qing","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng\u2010Hock","family":"Quak","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat \u2013 National University Children's Medical Institute National University Health System Singapore"},{"name":"Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion Margaret","family":"Aw","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat \u2013 National University Children's Medical Institute National University Health System Singapore"},{"name":"Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore 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