{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:36Z","timestamp":1753879596302,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data are limited on clinical outcomes in patients awaiting heart transplant (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) with total artificial heart (<jats:styled-content style=\"fixed-case\">TAH<\/jats:styled-content>) infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed all <jats:styled-content style=\"fixed-case\">TAH<\/jats:styled-content> recipients at our center. <jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content> was classified as <jats:italic>definite<\/jats:italic> if a microorganism was isolated in cultures from the exit site or deep tissues around the <jats:styled-content style=\"fixed-case\">TAH<\/jats:styled-content>; as <jats:italic>probable<\/jats:italic> in patients without surgical or microbiologic evidence of infection but no other explanation for persistent or recurrent bloodstream infection (<jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>); or <jats:italic>possible<\/jats:italic> in patients with clinical suspicion and radiographic findings suggestive of <jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content>, but without surgical intervention or microbiologic evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2012 to 2015, a total of 13 patients received a <jats:styled-content style=\"fixed-case\">TAH<\/jats:styled-content>, with a median age at implantation of 52\u00a0years (range: 28\u201060). <jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content> occurred in nine patients (seven definite, one probable, one possible) a median of 41\u00a0days after implant (range: 17\u2010475). The majority of <jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content>s were caused by <jats:italic>Staphylococcus<\/jats:italic> species. Seven of nine patients underwent <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> (four had pre\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> mediastinal washout, and five had positive <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> operative cultures). Three patients had an active <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> caused by the same pathogen causing <jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content> at the time of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, with one developing a post\u2010<jats:styled-content style=\"fixed-case\">HT BSI<\/jats:styled-content> with the same bacteria. No patient developed post\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> surgical site infection caused by the <jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content> pathogen. No deaths among <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> recipients were attributed to infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TAH infection<\/jats:styled-content> is frequently associated with <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content> and mediastinitis and <jats:italic>Staphylococcus<\/jats:italic> was the most common pathogen. A multimodal approach of appropriate pre\u2010 and post\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> antimicrobial therapy, surgical drainage, and heart transplantation with radical mediastinal debridement was successful in curing infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12801","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T08:16:40Z","timestamp":1510042600000},"source":"Crossref","is-referenced-by-count":6,"title":["Successful heart transplantation in patients with total artificial heart infections"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-7510","authenticated-orcid":false,"given":"Sarah","family":"Taimur","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-3586","authenticated-orcid":false,"given":"Timothy","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mennakshi","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Roldan","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Ashley","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Pinney","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anelechi","family":"Anyanwu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mount Sinai Hospital  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirish","family":"Huprikar","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases Icahn School of 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