{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:54:18Z","timestamp":1793015658674,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006441","name":"Center for Outcomes Research and Evaluation, Yale School of Medicine","doi-asserted-by":"publisher","award":["P30 CA021765"],"award-info":[{"award-number":["P30 CA021765"]}],"id":[{"id":"10.13039\/100006441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000985","name":"Assisi Foundation of Memphis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000985","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>T\u2010cell depletion (<jats:styled-content style=\"fixed-case\">TCD<\/jats:styled-content>) effectively reduces severe graft\u2010versus\u2010host disease in recipients of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010mismatched allografts. However, <jats:styled-content style=\"fixed-case\">TCD<\/jats:styled-content> is associated with delayed immune recovery and increased infections. We hypothesized that specific depletion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>+ naive T cells, rather than broad depletion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+ T cells, can preserve memory\u2010immunity in the allografts and confer protection against important viral infections in the early post\u2010transplant period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven patients who received <jats:styled-content style=\"fixed-case\">TCD<\/jats:styled-content> haploidentical donor transplantation for hematologic malignancy on 3 consecutive trials were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients receiving <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010depleted donor grafts had 2000\u2010fold more donor T cells infused, significantly higher T\u2010cell counts at Day +30 post transplant (550\/\u03bcL vs 10\/\u03bcL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and higher T\u2010cell diversity by Vbeta spectratyping at Day +100 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Importantly, these recipients experienced a significant reduction in both the incidence (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) and duration (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) of any viremia (cytomegalovirus, Epstein\u2010Barr virus, or adenovirus) in the first 6\u00a0months post transplant. Specifically, recipients of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3\u2010depleted grafts were more likely to experience adenovirus viremia (27% vs 4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010depletion provided a large number of donor memory T cells to the recipients and was associated with enhanced early T\u2010cell recovery and protection against viremia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12823","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T11:32:50Z","timestamp":1511782370000},"source":"Crossref","is-referenced-by-count":62,"title":["Selective T\u2010cell depletion targeting <scp>CD<\/scp>45<scp>RA<\/scp> reduces viremia and enhances early T\u2010cell recovery compared with <scp>CD<\/scp>3\u2010targeted T\u2010cell depletion"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9980","authenticated-orcid":false,"given":"Brandon M.","family":"Triplett","sequence":"first","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center College of Medicine  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane J.","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Moen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center College of Medicine  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Mamcarz","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center College of Medicine  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Shook","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center College of Medicine  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center College of Medicine  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall T.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center College of Medicine  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13868"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.01.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391702"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-564401"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240701644000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.87"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563817"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705650"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.09.027"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.114"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25352"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81229"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-016410"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-109678"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802212"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.139"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703619"},{"key":"e_1_2_8_21_1","first-page":"825","article-title":"1994 Consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530374"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1159"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02419.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000678"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703770"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:56:36Z","timestamp":1695473796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/tid.12823"],"URL":"https:\/\/doi.org\/10.1111\/tid.12823","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]},"article-number":"e12823"}}