{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:34:37Z","timestamp":1792028077441,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Pre\u2010transplant screening for latent tuberculosis infection (\n LTBI<\/jats:styled-content>\n ) is a complex consideration that varies by institution. Inconsistent performance of interferon\u2010gamma release assay (\n IGRA<\/jats:styled-content>\n ) further complicates screening. Data regarding\n LTBI<\/jats:styled-content>\n screening outcomes and test characteristics in a large, foreign\u2010born pre\u2010transplant population within the United States are limited.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this retrospective study, patients who received Quanti\n FERON<\/jats:styled-content>\n \u00ae<\/jats:sup>\n \u2010\n TB<\/jats:styled-content>\n Gold (\n QFT<\/jats:styled-content>\n ) prior to liver transplantation (\n LT<\/jats:styled-content>\n ) were included. Characteristics of patients were compared by\n QFT<\/jats:styled-content>\n result, and predictors of indeterminate results were evaluated. Similar comparisons were performed between patients who developed active\n TB<\/jats:styled-content>\n and those who did not.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 148 patients screened, the rate of positive, indeterminate, and negative testing was 13.5% (20\/148), 27% (40\/148), and 59% (88\/148), respectively. An indeterminate\n QFT<\/jats:styled-content>\n result was more than 16 times more likely in patients with a Model for End\u2010stage Liver Disease score >25 (odds ratio [\n OR<\/jats:styled-content>\n ] 16.7; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 2.1\u2010132.0;\n P<\/jats:italic>\n \u00a0=\u00a0.008) and more than 4 times when performed in our institution's lab compared with commercial lab (\n OR<\/jats:styled-content>\n 4.1; 95%\n CI<\/jats:styled-content>\n , 1.34\u201012.44;\n P<\/jats:italic>\n \u00a0=\u00a0.013). The overall\n TB<\/jats:styled-content>\n incidence was 1102\/100 000 transplant cases. No patient who developed active\n TB<\/jats:styled-content>\n had a positive\n QFT<\/jats:styled-content>\n . All were born outside of the United States (\n P<\/jats:italic>\n \u00a0=\u00a0.06) and had pre\u2010transplantation chest imaging demonstrating granulomatous disease (\n P<\/jats:italic>\n \u00a0=\u00a0.006).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our experience further highlights the challenges of\n LTBI<\/jats:styled-content>\n screening prior to\n LT<\/jats:styled-content>\n and suggests that\n QFT<\/jats:styled-content>\n may be a poor predictor of active\n TB<\/jats:styled-content>\n in higher risk pre\u2010transplant populations. Candidates should be screened as early as possible to optimize\n QFT<\/jats:styled-content>\n performance, and local epidemiological data should be used to create institution\u2010specific screening protocols in areas with large populations from\n TB<\/jats:styled-content>\n \u2010endemic regions. Management should consider\n TB<\/jats:styled-content>\n risk factors,\n QFT<\/jats:styled-content>\n , and imaging instead of reliance on\n QFT<\/jats:styled-content>\n testing alone.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12845","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T07:28:39Z","timestamp":1516692519000},"source":"Crossref","is-referenced-by-count":25,"title":["Tuberculosis after liver transplantation in a large center in New York City: Quanti\n FERON<\/scp>\n \u00ae<\/sup>\n \u2010\n TB<\/scp>\n Gold\u2010based pre\u2010transplant screening performance and active tuberculosis post\u2010transplant"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-9576","authenticated-orcid":false,"given":"Jonathan","family":"Hand","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Ochsner Clinic Foundation University of Queensland School of Medicine, Ochsner Clinical School New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sigel","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish","family":"Huprikar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Hamula","sequence":"additional","affiliation":[{"name":"Microbiology and Pathology Mount Sinai Health System\/Icahn School of Medicine at Mount Sinai New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i4.83"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064928"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12100"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199601270-00008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/514993"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit488"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21709"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209270-00029"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00666.x"},{"key":"e_1_2_7_11_1","unstructured":"New York City Department of Health and Mental Hygiene.Tuberculosis in New York City 2015. 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