{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:23:06Z","timestamp":1790734986259,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272200800007C"],"award-info":[{"award-number":["HHSN272200800007C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["HHSN27220080000C"],"award-info":[{"award-number":["HHSN27220080000C"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","award":["HHSN272200800001C"],"award-info":[{"award-number":["HHSN272200800001C"]}],"id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","award":["HHSN272200800008C"],"award-info":[{"award-number":["HHSN272200800008C"]}],"id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","award":["U54TR001356"],"award-info":[{"award-number":["U54TR001356"]}],"id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solid organ transplant recipients are at increased risk for reactivation of herpes zoster, or shingles, and have a higher frequency of serious complications including post\u2010herpetic neuralgia. A live, attenuated shingles vaccine is effective and approved for individuals 50\u00a0years and older. The vaccine is contraindicated following transplantation, but may be used in patients with renal failure. Utilization of the vaccine has been poor in patients with end\u2010stage renal disease, including those awaiting transplant, owing to concerns for safety, efficacy, and potential sensitization prior to transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a phase I, randomized, placebo\u2010controlled study of the safety and immunogenicity of live, attenuated Oka strain shingles vaccine in subjects prior to or awaiting renal transplant at 3<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>centers. Subjects received vaccine a minimum of 4\u00a0weeks prior to transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The vaccine was safe and well\u2010tolerated. There were no cases of herpes zoster or rash illness. There was no change in donor\u2010specific antibody or calculated panel reactive antibody after vaccination during the follow\u2010up period. There were no rejection episodes. There was a significant 2.1\u2010fold rise in geometric mean titer of anti\u2010<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>antibody at 5\u00a0weeks post\u2010vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data suggest that the shingles vaccine is safe in subjects with<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>awaiting transplant. Antibody responses were similar to those seen previously in adults &gt;50\u00a0years of age and are consistent with a protective response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12874","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T09:56:36Z","timestamp":1520416596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A randomized, placebo\u2010controlled phase I trial of live, attenuated herpes zoster vaccine in subjects with end\u2010stage renal disease immunized prior to renal transplantation"],"prefix":"10.1111","volume":"20","author":[{"given":"Geraldine","family":"Miller","sequence":"first","affiliation":[{"name":"Division of Infectious Disease Department of Medicine Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Yoder","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Research Program Department of Pediatrics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of Iowa Carver College of Medicine Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Winokur","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kotloff","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Tropical Pediatrics 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